ECC 与 CEU-骨骼肌细胞钙离子的后门新焦点。
ECC meets CEU-New focus on the backdoor for calcium ions in skeletal muscle cells.
机构信息
Institute of Applied Physiology, Ulm University, Ulm, Germany.
出版信息
J Gen Physiol. 2020 Oct 5;152(10). doi: 10.1085/jgp.202012679.
Abstract
In this issue, Michelucci et al. report the existence of specific sites acting as Ca entry units (CEUs) in fast skeletal muscle of mice lacking calsequestrin (CASQ1), the major Ca binding protein of the SR. The CEU provides constitutive and store-operated Ca entry (SOCE) and resistance to force decline resulting from SR Ca depletion during repetitive muscle activity.
摘要
本期杂志中，Michelucci 等人报道了在缺乏肌质网（SR）主要钙结合蛋白肌联蛋白（CASQ1）的小鼠快肌中存在特定的钙进入单位（CEU）。CEU 提供组成性和储存操纵钙内流（SOCE），并抵抗由于重复肌肉活动导致 SR 钙耗竭时的肌力下降。
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