Department of General Surgery, Children's Hospital of Shanghai, Shanghai Jiao Tong University, Shanghai, 200040, China.
Pediatr Surg Int. 2020 Oct;36(10):1167-1172. doi: 10.1007/s00383-020-04731-y. Epub 2020 Aug 26.
To explore the relationship between image-defined risk factors and surgical complications of localized neuroblastoma.
We retrospectively evaluated 84 patients who met the inclusion criteria at our hospitals between June 2014 and June 2019. Patients' clinic data were collected and the common terminology criteria for adverse events were used to categorize complications as major (grade 3-4) or minor (grade 1-2).
Four (11.8%) out of 34 stage L1 patients and 15 (30.0%) out of 50 stage L2 patients had surgical complications (P < 0.05). Seventy patents underwent primary surgery, including all stage L1 patients and 36 stage L2 patients. There were no significant differences between the two groups regarding surgical complications or major surgical complications. Among stage L2 patients, 2 (5.6%) out of 36 who underwent primary surgery and 2 (14.3%) out of 14 who underwent secondary surgery had major surgical complications (P < 0.05). Complete tumor resection was achieved in 18 (50%) and 7 (50%) patients in each group (P > 0.05). The mean numbers of IDRFs were 2.06 and 4.29, respectively (P < 0.05).
Localized neuroblastoma patients with IDRFs have a greater surgical risk. And the number of IDRFs is not ignorable, especially in predicting major surgical complications.
探讨局部神经母细胞瘤影像学定义的危险因素与手术并发症的关系。
我们回顾性评估了 2014 年 6 月至 2019 年 6 月期间在我院符合纳入标准的 84 例患者。收集患者的临床资料，采用不良事件常用术语标准对并发症进行分类，分为主要（3-4 级）或次要（1-2 级）并发症。
34 例 L1 期患者中有 4 例（11.8%），50 例 L2 期患者中有 15 例（30.0%）发生手术并发症（P<0.05）。70 例患者接受了原发性手术，包括所有 L1 期患者和 36 例 L2 期患者。两组间手术并发症或主要手术并发症无显著差异。在 L2 期患者中，接受原发性手术的 36 例中有 2 例（5.6%）和接受继发性手术的 14 例中有 2 例（14.3%）发生了主要手术并发症（P<0.05）。两组完全肿瘤切除率分别为 18 例（50%）和 7 例（50%）（P>0.05）。每组 IDRF 的平均数量分别为 2.06 和 4.29（P<0.05）。
有 IDRF 的局部神经母细胞瘤患者手术风险更大。IDRF 的数量不容忽视，尤其是在预测主要手术并发症方面。
