Naguib M, Farag H, Magbagbeola J A
Department of Anaesthesiology, King Faisal University, King Fahd Hospital, Kingdom of Saudi Arabia.
Middle East J Anaesthesiol. 1988 Feb;9(4):375-82.
Twenty patients were studied in a prospective double-blind randomized trial to determine the effects of intravenous lidocaine pretreatment on suxamethonium induced biochemical changes. Lidocaine 1 mg. kg-1 failed to attenuate changes in serum potassium, significantly decreased serum calcium, and prolonged duration of suxamethonium blockade. There were no significant changes in plasmacholinesterase activity or other biochemical parameters. It is concluded that pretreatment with 1 mg. kg-1 lidocaine failed to attenuate suxamethonium induced biochemical changes.
在一项前瞻性双盲随机试验中，对20名患者进行了研究，以确定静脉注射利多卡因预处理对琥珀酰胆碱诱导的生化变化的影响。1毫克/千克的利多卡因未能减轻血清钾的变化，显著降低血清钙，并延长了琥珀酰胆碱阻滞的持续时间。血浆胆碱酯酶活性或其他生化参数没有显著变化。得出的结论是，1毫克/千克利多卡因预处理未能减轻琥珀酰胆碱诱导的生化变化。
