颞骨癌：基于临床和组织学特征的新型预后评分

Temporal bone carcinoma: Novel prognostic score based on clinical and histological features.

作者信息

Zanoletti Elisabetta, Franz Leonardo, Cazzador Diego, Franchella Sebastiano, Calvanese Leonardo, Nicolai Piero, Mazzoni Antonio, Marioni Gino

机构信息

Department of Neuroscience DNS, Otolaryngology Section, Padova University, Padova, Italy.

Department of Neuroscience DNS, Section of Human Anatomy, Padova University, Padova, Italy.

出版信息

Head Neck. 2020 Dec;42(12):3693-3701. doi: 10.1002/hed.26435. Epub 2020 Aug 27.

DOI:10.1002/hed.26435

PMID:32851728

Abstract

BACKGROUND

This study aimed to develop a novel temporal bone squamous cell carcinoma (TBSCC) prognosis scoring system and compare it with the revised Pittsburgh staging system.

METHODS

Forty-four consecutive TBSCC patients were assessed to identify predictors of recurrence. Each predictor's hazard ratio for recurrence was used to develop our novel scoring system.

RESULTS

Based on variables with P < .10 in Cox's regression model, our score included: revised Pittsburgh stage; non-anterior spread of T4 carcinoma; dural involvement; and histological grade. A higher recurrence rate (P = .000) and shorter disease-free survival (P = .000) were associated with scores of ≥5. The area under the curve of our score was larger than that of the revised Pittsburgh stage for both recurrence and disease-specific mortality (P = .0178 and P = .0193, respectively).

CONCLUSION

Our TBSCC scoring system is based on variables that are obtainable preoperatively from clinical and radiological data and biopsies. Its prognostic value should be validated for published TBSCC series and then in prospective settings.

摘要

背景

本研究旨在开发一种新型颞骨鳞状细胞癌（TBSCC）预后评分系统，并将其与修订后的匹兹堡分期系统进行比较。

方法

对44例连续的TBSCC患者进行评估，以确定复发的预测因素。每个预测因素的复发风险比用于开发我们的新型评分系统。

结果

基于Cox回归模型中P < 0.10的变量，我们的评分包括：修订后的匹兹堡分期；T4癌的非前部扩散；硬脑膜受累；以及组织学分级。评分≥5与更高的复发率（P = 0.000）和更短的无病生存期（P = 0.000）相关。对于复发和疾病特异性死亡率，我们评分的曲线下面积均大于修订后的匹兹堡分期（分别为P = 0.0178和P = 0.0193）。