Li Bin, Lu Ying-Ying, Lo Jen-Yu, Qiao Xue, Ye Min
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China.
J Asian Nat Prod Res. 2021 Jul;23(7):666-674. doi: 10.1080/10286020.2020.1810673. Epub 2020 Aug 27.
One new meroterpenoid, antroquinonol Y (), a new ergostane-type sterol, antcamphin Y (), and a new ergostane-type triterpenoid, antcamphin Z (), together with 10 known ones (), were isolated from the dish-cultured fungus . Their structures were characterized by extensive NMR and HRESIMS data analyses. The absolute configurations were elucidated by experimental and calculated electronic circular dichroism (ECD) spectral analyses and chemical semi-synthesis. Compounds , , and exhibited potent inhibitory activities against four human cancer cell lines (U251, HL60, SW480, and A549 cells) with IC values of 4.6 to 11.7 μM.
从盘培养真菌中分离出一种新的半萜类化合物antroquinonol Y（）、一种新的麦角甾烷型甾醇antcamphin Y（）和一种新的麦角甾烷型三萜类化合物antcamphin Z（），以及10种已知化合物（）。通过广泛的核磁共振（NMR）和高分辨电喷雾电离质谱（HRESIMS）数据分析对它们的结构进行了表征。通过实验和计算的电子圆二色（ECD）光谱分析以及化学半合成阐明了其绝对构型。化合物、和对四种人类癌细胞系（U251、HL60、SW480和A549细胞）表现出较强的抑制活性，IC值为4.6至11.7μM。
