Gong Jian, Yan Zhangren, Liu Qiao
School of Clinical Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, China.
Department of Dermatology, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, China.
J Int Med Res. 2020 Aug;48(8):300060520929170. doi: 10.1177/0300060520929170.
The Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology-1 (EVH-1) domain (SPRED) family of proteins was discovered in 2001. These Sprouty-related tyrosine kinase-binding proteins negatively regulate a variety of growth factor-induced Ras/ERK signaling pathways. In recent years, SPRED proteins have been found to regulate vital activities such as cell development, movement, and proliferation, and to participate in pathophysiological processes such as tumor metastasis, hematopoietic regulation, and allergic reactions. The findings of these studies have important implications regarding the involvement of SPRED proteins in disease. Early studies of SPRED proteins focused mainly on various tumors, cardiovascular diseases, and organ development. However, in recent years, great progress has been made in elucidating the role of SPRED proteins in neuropsychiatric, inflammatory, endocrine, and ophthalmic diseases. This article provides a review of the experimental studies performed in recent years on the SPRED proteins and their role in the pathogenesis of certain diseases.
与Sprouty相关的Ena/血管舒张剂刺激磷蛋白同源结构域1（EVH-1）蛋白家族于2001年被发现。这些与Sprouty相关的酪氨酸激酶结合蛋白对多种生长因子诱导的Ras/ERK信号通路起负向调节作用。近年来，已发现SPRED蛋白可调节细胞发育、运动和增殖等重要活动，并参与肿瘤转移、造血调节和过敏反应等病理生理过程。这些研究结果对于SPRED蛋白在疾病中的作用具有重要意义。早期对SPRED蛋白的研究主要集中在各种肿瘤、心血管疾病和器官发育方面。然而，近年来在阐明SPRED蛋白在神经精神、炎症、内分泌和眼科疾病中的作用方面取得了很大进展。本文综述了近年来对SPRED蛋白及其在某些疾病发病机制中作用的实验研究。
