与静脉注射咪达唑仑相关的术后表达性失语：一项5年回顾性病例对照研究。

Postoperative expressive aphasia associated with intravenous midazolam administration: a 5-year retrospective case-control study.

作者信息

Oh Saecheol, Chung Jihyun, Baek Sujin, Park Yoo Jung

机构信息

Department of Anesthesiology and Pain Medicine, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Department of Anesthesiology and Pain Medicine, Saint Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

出版信息

J Int Med Res. 2020 Aug;48(8):300060520948751. doi: 10.1177/0300060520948751.

DOI:10.1177/0300060520948751

PMID:32851907

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7457656/

Abstract

OBJECTIVES

This study aimed to investigate the epidemiology of intravenous midazolam-induced postoperative expressive aphasia (EA).

METHODS

The incidence rate, risk ratio, and contributing factors to intravenous midazolam-induced postoperative EA were analyzed retrospectively in 6756 orthopedic patients. A telephone interview was conducted with patients with EA after surgery.

RESULTS

Patients were allocated to either the midazolam group (n = 6178) or no-midazolam group (n = 578). Twelve patients developed EA in the midazolam group, with an incidence of 0.19%, and no patient developed EA in the no-midazolam group. The mean age of EA patients was 70 years, and 92% were women. Among them, 75% received general anesthesia, and the mean dose of midazolam was 1.8 mg. EA was reversed in nine of 12 (75%) patients within 4 minutes of flumazenil administration, and >60 minutes were required to reverse EA in the other three patients (25%).

CONCLUSION

Intravenous midazolam administration for preoperative sedation caused transient EA in 0.19% of patients, especially elderly women who received general anesthesia, and EA could be reversed by flumazenil.

摘要

目的

本研究旨在调查静脉注射咪达唑仑所致术后表达性失语（EA）的流行病学情况。

方法

对6756例骨科患者进行回顾性分析，以确定静脉注射咪达唑仑所致术后EA的发生率、风险比及相关影响因素。对术后发生EA的患者进行电话随访。

结果

患者被分为咪达唑仑组（n = 6178）和非咪达唑仑组（n = 578）。咪达唑仑组有12例患者发生EA，发生率为0.19%，非咪达唑仑组无患者发生EA。EA患者的平均年龄为70岁，92%为女性。其中，75%接受全身麻醉，咪达唑仑的平均剂量为1.8mg。12例患者中有9例（75%）在注射氟马西尼后4分钟内EA症状得到缓解，另外3例患者（25%）则需要超过60分钟才能缓解。