Departments of Plastic and Reconstructive and Aesthetic Surgery, and.
Pathology, Faculty of Meram Medicine, Necmettin Erbakan University, Konya, Turkey.
Dermatol Surg. 2020 Dec;46(12):1661-1666. doi: 10.1097/DSS.0000000000002600.
Botulinum toxin has long been known for its paralytic effects at the neuromuscular junction. Although it has been widely used for vascular and nervous tissues, there has been no study of the aesthetic effects of the application of ethanol to muscle tissues to date.
The authors aimed to demonstrate the effects of the application of ethanol to muscle tissues after an intramuscular injection and to compare the effects of botulinum toxin A (BTA) and ethanol.
A total of 28 rabbits were divided into 4 groups (n = 7 each). Botulinum toxin A (5 units) and different concentrations of ethanol (5 cc) were injected into the left and right anterior auricular muscles of all rabbits, respectively. Ear ptosis was assessed, and histopathological examination was performed after all rabbits were euthanized in the eighth week.
Muscle function was affected earlier in ethanol-treated ears than in botulinum-treated ears; however, the ptotic effect lasted for a significantly shorter duration in ethanol-injected ears than in BTA-applied ears.
Ethanol can block muscle function reversibly and can serve as an alternative to BTA, particularly when rapid results are desirable.
肉毒毒素早已因其在神经肌肉接头的麻痹作用而为人所知。尽管它已被广泛应用于血管和神经组织，但迄今为止，尚无关于将乙醇应用于肌肉组织的美学效果的研究。
作者旨在展示肌肉内注射乙醇后对肌肉组织的影响，并比较肉毒毒素 A（BTA）和乙醇的效果。
共 28 只兔子被分为 4 组（每组 7 只）。所有兔子的左右耳前肌分别注射肉毒毒素 A（5 单位）和不同浓度的乙醇（5 cc）。评估耳下垂，所有兔子在第 8 周安乐死后进行组织病理学检查。
乙醇处理的耳朵中肌肉功能受影响的时间早于肉毒毒素处理的耳朵，但乙醇注射耳朵中的下垂效果持续时间明显短于 BTA 应用耳朵。
乙醇可使肌肉功能可逆性受阻，可替代 BTA，特别是在需要快速结果时。
