3rd Department of Internal Medicine, Papageorgiou Hospital, Aristotle University of Thessaloniki, Ring Road Nea Eukarpia, 56403, Thessaloniki, Greece.
Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, 3459 Fifth Avenue, Pittsburgh, PA, 15213, USA.
Curr Hypertens Rep. 2020 Aug 27;22(9):71. doi: 10.1007/s11906-020-01075-9.
Summarize the methods used for measurement of cerebral blood flow and oxygenation; describe the effects of hypertension on cerebral blood flow and oxygenation.
Information regarding the effects of hypertension on cerebrovascular circulation during exercise is very limited, despite a plethora of methods to help with its assessment. In normotensive individuals performing incremental exercise testing, total blood flow to the brain increases. In contrast, the few studies performed in hypertensive patients suggest a smaller increase in cerebral blood flow, despite higher blood pressure levels. Endothelial dysfunction and increased vasoconstrictor concentration, as well as large vessel atherosclerosis and decreased small vessel number, have been proposed as the underlying mechanisms. Hypertension may adversely impact oxygen and blood delivery to the brain, both at rest and during exercise. Future studies should utilize the newer, noninvasive techniques to better characterize the interplay between the brain and exercise in hypertension.
总结用于测量脑血流和氧合的方法；描述高血压对脑血流和氧合的影响。
尽管有很多方法可以帮助评估高血压，但关于高血压对运动期间脑血管循环的影响的信息非常有限。在进行递增运动测试的正常血压个体中，脑总血流量增加。相比之下，在高血压患者中进行的少数研究表明，尽管血压水平较高，但脑血流量的增加较小。内皮功能障碍和血管收缩剂浓度增加，以及大血管粥样硬化和小血管数量减少，被认为是潜在的机制。高血压可能会对大脑在休息和运动时的氧气和血液供应产生不利影响。未来的研究应该利用更新的、非侵入性技术来更好地描述高血压患者大脑与运动之间的相互作用。
