Division of Nephrology, University of Virginia School of Medicine, Charlottesville, Virginia.
Division of Kidney Disease and Hypertension, Zucker School of Medicine at Hofstra University, Great Neck, New York.
CA Cancer J Clin. 2021 Jan;71(1):47-77. doi: 10.3322/caac.21636. Epub 2020 Aug 27.
Onconephrology is a new subspecialty of nephrology that recognizes the important intersections of kidney disease with cancer. This intersection takes many forms and includes drug-induced nephrotoxicity, electrolyte disorders, paraneoplastic glomerulonephritis, and the interactions of chronic kidney disease with cancer. Data clearly demonstrate that, when patients with cancer develop acute or chronic kidney disease, outcomes are inferior, and the promise of curative therapeutic regimens is lessened. This highlights the imperative for collaborative care between oncologists and nephrologists in recognizing and treating kidney disease in patients with cancer. In response to this need, specific training programs in onconephrology as well as dedicated onconephrology clinics have appeared. This comprehensive review covers many of the critical topics in onconephrology, with a focus on acute kidney injury, chronic kidney disease, drug-induced nephrotoxicity, kidney disease in stem cell transplantation, and electrolyte disorders in patients with cancer.
肿瘤肾脏病学是肾脏病学的一个新兴亚专业,它认识到肾脏疾病与癌症之间的重要交叉点。这种交叉点有多种形式,包括药物性肾毒性、电解质紊乱、副肿瘤性肾小球肾炎以及慢性肾脏病与癌症的相互作用。数据清楚地表明,当癌症患者出现急性或慢性肾脏病时,其预后较差,治愈性治疗方案的效果也会降低。这凸显了肿瘤学家和肾脏病学家在识别和治疗癌症患者肾脏病方面进行协作的必要性。为了满足这一需求,已经出现了专门的肿瘤肾脏病学培训项目和诊所。这篇全面的综述涵盖了肿瘤肾脏病学的许多关键主题,重点介绍了急性肾损伤、慢性肾脏病、药物性肾毒性、干细胞移植患者的肾脏病以及癌症患者的电解质紊乱。