University of Khartoum, Khartoum Sudan.
University of Khartoum, Khartoum Sudan.
Ann Pharm Fr. 2021 Jan;79(1):28-35. doi: 10.1016/j.pharma.2020.08.004. Epub 2020 Aug 24.
The aim of the current study was to compare the physicochemical and disintegrant properties of pearl millet starch with other starches using paracetamol as model drug.
Determination of percentage yield, Physicochemical, micrometrics characteristics of starch/granules, drug excipients compatibility studies and evaluation of prepared paracetamol tablets were measured using official techniques.
The yield of the millet starch ranged from 30 to 40%. Moisture content 8.77%, pH 5.7, Swelling capacity 1.2, Hydration capacity 1.748, Moisture uptake 11.8%, Amylose 24.6%, with poor flowability and compressibility. No significant difference in hardness, friability% & disintegration times for formulations containing millet starch to that containing potato and maize starch (P>0.05).
From the study, Millet seeds locally cultivated in Sudan gave a high yield of starch, has same physicochemical properties as maize and potato starch so can be used as an alternative to those starches.
本研究旨在使用对乙酰氨基酚作为模型药物，比较珍珠粟淀粉与其他淀粉的物理化学和崩解特性。
采用官方技术测定淀粉/颗粒的产率、物理化学、微观特性、药物赋形剂相容性研究和制备的对乙酰氨基酚片的评估。
小米淀粉的产率在 30%至 40%之间。水分含量为 8.77%，pH 值为 5.7，溶胀能力为 1.2，水合能力为 1.748，吸水率为 11.8%，直链淀粉为 24.6%，流动性和可压缩性差。含有小米淀粉的制剂的硬度、脆碎度%和崩解时间与含有马铃薯和玉米淀粉的制剂无显著差异（P>0.05）。
从这项研究中可以看出，在苏丹当地种植的小米种子可以获得高产淀粉，其物理化学性质与玉米和马铃薯淀粉相同，因此可以作为这些淀粉的替代品。
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