Bos C E, Bolhuis G K, Van Doorne H, Lerk C F
Laboratory for Pharmaceutical Technology and Dispensing, State University of Groningen, The Netherlands.
Pharm Weekbl Sci. 1987 Oct 16;9(5):274-82. doi: 10.1007/BF01953630.
Maize, potato, rice and tapioca (cassava) starch were evaluated with respect to their properties on direct compression. Rice starch showed much better compactibility as compared to maize, potato and tapioca starch. Moreover, its binding capacity proved to be almost insensitive to mixing with magnesium stearate. This in contrast to the dramatic decrease in crushing strength of potato starch tablets containing the lubricant. The compactibility of the starches was found to be strongly affected by the equilibrium moisture content of the starches, which is dependent on the relative humidity of the atmosphere under which the powders were stored. All starches showed adequate capacity for water uptake to act as a disintegrant. Rice starch exhibited worst flowability, caused by its fine particle size as compared to the other starches. Granulation of rice starch changed it into a potential filler-binder in tablets prepared by direct compression.
对玉米淀粉、马铃薯淀粉、大米淀粉和木薯淀粉的直接压片性能进行了评估。与玉米淀粉、马铃薯淀粉和木薯淀粉相比，大米淀粉表现出更好的可压性。此外，其结合能力被证明与硬脂酸镁混合时几乎不敏感。这与含有润滑剂的马铃薯淀粉片的抗压强度急剧下降形成对比。发现淀粉的可压性受淀粉平衡水分含量的强烈影响，而平衡水分含量取决于储存粉末时大气的相对湿度。所有淀粉都表现出足够的吸水能力以作为崩解剂。与其他淀粉相比，大米淀粉由于其细颗粒尺寸而表现出最差的流动性。大米淀粉制粒后变成了直接压片制备的片剂中一种潜在的填充剂-粘合剂。
