Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Zip Code 60440-900 Fortaleza, CE, Brazil.
Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Zip Code 60440-900 Fortaleza, CE, Brazil; Federal Institute of Education, Science and Technology of Ceará, Campus Quixadá, Quixadá, CE Zip Code 63902-580, Brazil.
Int J Biol Macromol. 2020 Dec 1;164:2813-2817. doi: 10.1016/j.ijbiomac.2020.08.184. Epub 2020 Aug 24.
This work proposes the development of a starch-based drug carrier for fluoxetine (FLX) delivery and evaluate the improvement of the drug antibacterial activity. The starch nanocapsules were prepared via interfacial polyaddition reaction presenting a core-shell morphology, based on polyurethane linkage, with a particle size in the range 250-300 nm. Furthermore, FLX-loaded nanocapsules were evaluated regarding antibacterial potential against Staphylococcus aureus (ATCC® 6538P ™) and its clinical strains of methicillin-resistant. As expected, the FLX-loaded presented lower minimum inhibitory concentration (MIC) values, in the range of 190-95 μg mL, against all isolated microorganisms in comparison to FLX, 255 μg mL. According to results, the FLX-loaded starch nanocapsules have successfully improved drug antibacterial activity, generating promising perspectives on the field of the hydrophilic drug delivery systems.
本工作提出了一种基于淀粉的药物载体用于氟西汀（FLX）的传递，并评估了药物抗菌活性的提高。通过界面聚加成反应制备了淀粉纳米胶囊，具有基于聚氨酯键的核壳形态，粒径在 250-300nm 范围内。此外，还评估了载有 FLX 的纳米胶囊在对抗金黄色葡萄球菌（ATCC®6538P ™）及其耐甲氧西林的临床菌株方面的潜在抗菌作用。正如预期的那样，与 FLX 相比，所有分离的微生物的载有 FLX 的纳米胶囊的最低抑菌浓度（MIC）值均在 190-95μgmL 的范围内有所降低。根据结果，载有 FLX 的淀粉纳米胶囊成功地提高了药物的抗菌活性，为亲水性药物传递系统领域带来了广阔的前景。
