miR-27a 多态性与消化系统癌症风险的关联。

Association of miR-27a polymorphism with the risk of digestive system cancers.

机构信息

Department of Clinical Epidemiology, First Affiliated Hospital, China Medical University, Shenyang, 110001, China; Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110122, China.

Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110122, China.

出版信息

Pathol Res Pract. 2020 Oct;216(10):153115. doi: 10.1016/j.prp.2020.153115. Epub 2020 Jul 13.

DOI:10.1016/j.prp.2020.153115

PMID:32853952

Abstract

BACKGROUND

Cancer of the digestive system is a common cancer and results in high mortality rates world-wide. miR-27a polymorphism has been associated with an increased risk of digestive system cancers; however, this has not been conclusively shown yet. Therefore, to clarify this, we conducted a comprehensive meta-analysis.

METHODS

PubMed, EMBASE, OVID and Cochrane Library databases were comprehensively searched to retrieve eligible studies published up to May 10, 2020 that referred to digestive cancers. Odds ratios and the corresponding 95 % confidence intervals (CI) were used when calculating the relationship between miR-27a rs895819 polymorphism and susceptibility to digestive cancers.

RESULTS

A significant correlation between the miR-27a rs895819 polymorphism and the presence of digestive system cancers was found in four genetic models, which were the homozygote, dominant, recessive, and allele genetic models (GG vs AA: OR = 1.210, 95 %CI = 1.020-1.436, P = 0.029; GG + AG vs AA: OR = 1.092, 95 %CI = 1.024-1.164, P = 0.007; GG vs AG + AA: OR = 1.182, 95 %CI = 1.005-1.390, P = 0.044; G vs A: OR = 1.099, 95 %CI = 1.046-1.154, P < 0.001). Hierarchical analysis by ethnicity suggested that miR-27a rs895819 significantly increased the risk of digestive system cancers in the Asian population, but not in Caucasians. Additionally, rs895819 polymorphism was found to be significantly associated with colorectal cancer and gastric cancer.

CONCLUSIONS

The miR-27a rs895819 polymorphism may be associated with an increased risk for digestive system cancers.

摘要

背景

消化系统癌症是一种常见的癌症，在全球范围内导致高死亡率。miR-27a 多态性与消化系统癌症的风险增加有关，但尚未得到明确证实。因此，为了澄清这一点，我们进行了一项综合荟萃分析。

方法

全面检索了 PubMed、EMBASE、OVID 和 Cochrane Library 数据库，以检索截至 2020 年 5 月 10 日发表的与消化系统癌症相关的合格研究。使用比值比和相应的 95%置信区间（CI）来计算 miR-27a rs895819 多态性与消化系统癌症易感性之间的关系。

结果

在四种遗传模型中，miR-27a rs895819 多态性与消化系统癌症的存在之间存在显著相关性，这些遗传模型是纯合子、显性、隐性和等位基因遗传模型（GG 与 AA：OR = 1.210，95%CI = 1.020-1.436，P = 0.029；GG + AG 与 AA：OR = 1.092，95%CI = 1.024-1.164，P = 0.007；GG 与 AG + AA：OR = 1.182，95%CI = 1.005-1.390，P = 0.044；G 与 A：OR = 1.099，95%CI = 1.046-1.154，P < 0.001）。按种族进行分层分析表明，miR-27a rs895819 在中国人群中显著增加了消化系统癌症的风险，但在白种人中没有。此外，rs895819 多态性与结直肠癌和胃癌显著相关。