Galbally Megan, Watson Stuart J, Keelan Jeff, MacMillan Kelli K, Power Josephine, IJzendoorn Marinus van, Lewis Andrew J
College of Science, Health, Engineering and Education, Murdoch University, Australia; School of Medicine, University of Notre Dame, Australia; King Edward Memorial Hospital, Subiaco, Australia; Women and Infants Research Foundation, Carson House, Subiaco, Australia.
College of Science, Health, Engineering and Education, Murdoch University, Australia; School of Medicine, University of Notre Dame, Australia.
J Psychiatr Res. 2020 Nov;130:247-253. doi: 10.1016/j.jpsychires.2020.07.010. Epub 2020 Jul 29.
Oxytocin has been a hormone of interest in understanding both depression and parenting. Here, the role of oxytocin has been explored in understanding the interaction between perinatal depression, history of trauma and subsequent longer-term child socio-emotional outcomes. Data were obtained from 203 pregnant women from the Mercy Pregnancy and Emotional Wellbeing Study (MPEWS), a pregnancy cohort study with data collected across pregnancy, postpartum and until 4 years for mother and child. Maternal antenatal depression was measured using the Structured Clinical Interview for DSM-IV (SCID-IV) together with the Childhood Trauma Questionnaire to measure maternal trauma history. Maternal oxytocin levels were measured by enzyme immunoassay following extraction at four time points across pregnancy and the postpartum. The offspring consisted of 203 children followed up from birth until 4 years of age when they were assessed for DSM 5 depression and anxiety disorders (emotional disorders) using the Preschool Age Psychiatric Assessment. Maternal oxytocin levels increased over pregnancy and the postpartum in both control and depressed women with no difference between groups. Maternal childhood trauma and antenatal antidepressant use was also not associated with maternal oxytocin levels. Lower gestational age, maternal depression and early childhood trauma, and late pregnancy oxytocin concentrations were associated with later childhood emotional disorders; together they predicted 10% of variance for emotional disorders. Oxytocin is a hormone whose role in understanding intergenerational risk from pregnancy to child emotional disorders is dependent on relational context. Future research can expand on understanding these important early predictors of childhood mental health.
催产素一直是人们在理解抑郁症和育儿方面感兴趣的一种激素。在此，我们探讨了催产素在理解围产期抑郁症、创伤史与随后长期儿童社会情感结局之间相互作用中的作用。数据来自于“慈悲怀孕与情绪健康研究”（MPEWS）中的203名孕妇，这是一项怀孕队列研究，收集了母亲和孩子在整个孕期、产后直至4岁的数据。使用《精神疾病诊断与统计手册》第四版（DSM-IV）的结构化临床访谈以及儿童创伤问卷来测量母亲的产前抑郁症和创伤史。在孕期和产后的四个时间点提取样本后，通过酶免疫测定法测量母亲的催产素水平。子代包括203名儿童，从出生开始随访至4岁，使用学龄前儿童精神病学评估对他们进行DSM-5抑郁症和焦虑症（情绪障碍）评估。对照组和抑郁症组女性的母亲催产素水平在孕期和产后均有所升高，两组之间无差异。母亲童年创伤和产前抗抑郁药使用也与母亲催产素水平无关。较低的孕周、母亲抑郁症和童年早期创伤以及孕晚期催产素浓度与儿童后期情绪障碍有关；它们共同预测了情绪障碍10%的变异。催产素是一种激素，其在理解从怀孕到儿童情绪障碍的代际风险中的作用取决于关系背景。未来的研究可以进一步深入理解这些儿童心理健康的重要早期预测因素。
