[Effect of various types of vagotomy on prostaglandins (E, F2 alpha), thromboxane and prostacyclin synthesis in the mucosa of the gastroduodenal zone in experimental ulcer in the rat].

Synthesis of prostaglandins E2 and F2 alpha (PGE2, PGF2 alpha) thromboxane B2 (TXB2) and prostacycline (PGI) was studied in mucose of gastroduodenal area under conditions of experimental ulcer in rats after complete truncal vagotomy as well as after incomplete vagotomy involving dissection of one vagus trunk, proximal selective dissection, dissection of vagus nerve. Estimation of PGE2, PGF2 alpha, TXB2 and PGI biosynthesis in mucose of stomach fundal and anthral parts and in duodenal mucose showed that dissection of vagus nerve, as compared with complete truncal vagotomy or with dissection of one vagus trunk, was the most effective type of operation in ulcers of duodenum. After this operation the synthesis of the eucosanoids (PGE2 and PGI) was activated, which caused cytoprotective and secrete-regulating effects, while production of PGE2 and TXB2 alpha (the tissue-deteriorating substances) was inhibited. Dissection of vagus nerve appears to contribute to secretion of hydrogen chloride in stomach as well as to accelerate reparative processes in gastroduodenal mucose via the metabolic mechanisms studied.