[使用度普利尤单抗治疗同时发生的荨麻疹和特应性皮炎]

[Treatment of simultaneously occurring urticaria and atopic dermatitis with dupilumab].

作者信息

Föhr Julia, Herbst Matthias, Jahn Sigbert

机构信息

Dermatologische Praxis Dr. Herbst & Kollegen, Rheinstr. 7-9, 64283, Darmstadt, Deutschland.

出版信息

Hautarzt. 2021 Mar;72(3):249-251. doi: 10.1007/s00105-020-04675-3.

DOI:10.1007/s00105-020-04675-3

PMID:32856123

Abstract

Our 21-year-old woman presented with symptoms of chronic spontaneous urticaria with angioedema and of cholinergic urticaria as well as of atopic dermatitis. Treatment with the IgE antibody omalizumab resulted in an improvement of urticaria; however, relapses of the atopic dermatitis occurred. The use of the monoclonal IL-4/13 receptor antibody dupilumab resulted in complete healing of the atopic dermatitis, complete remission of the chronic spontaneous urticaria with angioedema, and the satisfactory control of cholinergic flare ups over a follow-up period of 26 weeks.

摘要

我们的这位21岁女性患者表现出慢性自发性荨麻疹伴血管性水肿、胆碱能性荨麻疹以及特应性皮炎的症状。使用IgE抗体奥马珠单抗治疗后荨麻疹有所改善；然而，特应性皮炎出现了复发。使用单克隆IL-4/13受体抗体度普利尤单抗后，特应性皮炎完全治愈，慢性自发性荨麻疹伴血管性水肿完全缓解，并且在26周的随访期内胆碱能发作得到了满意的控制。