Chia Justin C, Mydlarski P Régine
a Division of Dermatology, Department of Medicine , University of Calgary , Calgary , Alberta , Canada.
J Dermatolog Treat. 2017 Jun;28(4):332-337. doi: 10.1080/09546634.2016.1249819. Epub 2016 Nov 7.
Omalizumab is a recombinant humanized monoclonal antibody that inhibits the binding of immunoglobulin E (IgE) to the high-affinity IgE receptor (FceRI) on the surface of mast cells and basophils. Omalizumab has been approved for use in asthma, and new reports show promise in a variety of dermatologic diseases. Herein, we review the literature on omalizumab in dermatology and discuss the safety, efficacy and mechanisms of action for this emerging therapy.
PubMED, MEDLINE and Embase databases were searched for the period 1 January 1990 to 1 September 2016. Articles sourced were graded according to the Oxford Center for Evidence-Based Medicine Levels of Evidence Grades of Recommendation criteria.
A total of 99 articles met our inclusion criteria. They included reports on the use of omalizumab in chronic spontaneous urticaria, atopic dermatitis, mastocytosis, hyper-IgE syndrome, bullous pemphigoid, Netherton syndrome, urticarial vasculitis, Churg-Strauss syndrome and toxic epidermal necrolysis.
Omalizumab is effective in a variety of recalcitrant immune-mediated and autoimmune skin disorders. It is a safe and effective treatment for use in chronic idiopathic urticaria (Grade of recommendation: A). Randomized clinical trials with long-term follow-ups are warranted to firmly establish the role of omalizumab in the treatment of dermatologic disease.
奥马珠单抗是一种重组人源化单克隆抗体，可抑制免疫球蛋白E（IgE）与肥大细胞和嗜碱性粒细胞表面的高亲和力IgE受体（FceRI）结合。奥马珠单抗已被批准用于哮喘治疗，新的报道显示其在多种皮肤病中也有应用前景。在此，我们综述奥马珠单抗在皮肤病学领域的文献，并探讨这种新兴疗法的安全性、有效性及作用机制。
检索了1990年1月1日至2016年9月1日期间的PubMed、MEDLINE和Embase数据库。根据牛津循证医学中心证据水平和推荐等级标准对所获文章进行分级。
共有99篇文章符合我们的纳入标准。这些文章包括关于奥马珠单抗在慢性自发性荨麻疹、特应性皮炎、肥大细胞增多症、高IgE综合征、大疱性类天疱疮、Netherton综合征、荨麻疹性血管炎、Churg-Strauss综合征和中毒性表皮坏死松解症中的应用报道。
奥马珠单抗在多种难治性免疫介导和自身免疫性皮肤病中有效。它是治疗慢性特发性荨麻疹的一种安全有效的疗法（推荐等级：A）。有必要进行长期随访的随机临床试验，以明确奥马珠单抗在皮肤病治疗中的作用。
