Orthopaedic Division, Department of Public Health, University of Naples Federico II, Naples, Italy.
J Biol Regul Homeost Agents. 2020 May-Jun;34(3 Suppl. 2):15-21. ADVANCES IN MUSCULOSKELETAL DISEASES AND INFECTIONS - SOTIMI 2019.
Polyvinyl alcohol hydrogel implants (also known as Synthetic Cartilage Implant or Cartiva® have been described in the treatment of degeneration of the first and second metatarsophalangeal joint (MTPJ). We reviewed literature to report characteristics of devices on the market and investigate their efficacy and safety. Following the PRISMA checklist, the Medline and Scopus databases were searched, including studies reporting use of Cartiva® for treating joint degeneration of the first and second MPTJ. Studies were searched for surgical technique, postoperative protocol, clinical scores, complications and reoperations. We found that, although some studies suggest that the use of Synthetic Cartilage Implant (Cartiva® is effective in the treatment of hallux rigidus in providing symptoms relief without sacrifice of joint motion, the redundancy of cohorts reported in studies and the frequency of conflict of interest reported by authors weaken the strength of evidence available and warrant further studies. Regarding the treatment of the second MTPJ ailments, no recommendation can be formulated to date due to the lack of primary studies.
聚乙烯醇水凝胶植入物（也称为合成软骨植入物或 Cartiva®）已被用于治疗第一和第二跖趾关节（MTPJ）的退行性变。我们回顾了文献，报告了市场上器械的特点，并研究了它们的疗效和安全性。根据 PRISMA 清单，我们检索了 Medline 和 Scopus 数据库，包括报告使用 Cartiva®治疗第一和第二 MPTJ 关节退行性变的研究。研究了手术技术、术后方案、临床评分、并发症和再次手术。我们发现，尽管一些研究表明，在不牺牲关节运动的情况下，使用合成软骨植入物（Cartiva®）治疗僵硬拇趾有效，可以缓解症状，但研究中报告的队列冗余和作者报告的利益冲突频率削弱了现有证据的强度，需要进一步研究。关于第二跖趾关节疾病的治疗，由于缺乏主要研究，目前还不能提出建议。
