亚磺酰胺到亚磺酰胺酯的氮转移合成。
Synthesis of Sulfinamidines and Sulfinimidate Esters by Transfer of Nitrogen to Sulfenamides.
机构信息
Flow Chemistry and Microreactor Technology FLAME-Lab, Department of Pharmacy - Drug Sciences, University of Bari "A. Moro" Via E. Orabona 4, Bari, I - 70125, Italy.
DICATECh, Politecnico di Bari, Via E. Orabona 4, Bari 70125, Italy.
出版信息
Org Lett. 2020 Sep 18;22(18):7129-7134. doi: 10.1021/acs.orglett.0c02471. Epub 2020 Aug 28.
In this work we report a new synthetic tactic for the straightforward preparation of hardly accessible sulfinamidines and sulfinamide esters, by using a simple metal-free protocol. The process is robust and uses readily available sulfenamides as the S-donor and sulfonyloxycarbamates as the N-source. The scope and mechanism have also been investigated.
在这项工作中，我们报告了一种新的合成策略，通过使用简单的无金属方法，直接制备难以获得的亚磺酰胺和亚磺酰胺酯。该过程稳健，使用易得的亚磺酰胺作为 S 供体，磺酰氧基氨基甲酸酯作为 N 源。还研究了其范围和机理。
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