3989Baylor College of Medicine, Houston, TX, USA.
3984Texas Childrens Hospital, Houston, TX, USA.
Int J Surg Pathol. 2021 Jun;29(4):433-437. doi: 10.1177/1066896920953620. Epub 2020 Aug 28.
Adult granulosa cell tumor (AGCT) and sex cord tumor with annular tubules (SCTAT) are distinct sex cord stromal tumors with different molecular signatures. We present a unique case of an incidental ovarian tumor with mixed AGCT and SCTAT morphologic patterns. Due to the unusual co-occurrence, molecular testing was separately performed on both components. Despite minimal overlap in morphology, both the SCTAT and AGCT components were found to have an identical mutation profile, including the prototypical p.C134W mutation characteristic of AGCT. We thus present the first report of AGCT with SCTAT-like pattern.
成人颗粒细胞瘤 (AGCT) 和伴有环形小管的性索肿瘤 (SCTAT) 是具有不同分子特征的不同的性索间质肿瘤。我们报告了一例偶然发现的具有混合 AGCT 和 SCTAT 形态学模式的卵巢肿瘤的独特病例。由于这种不常见的共存，对两种成分分别进行了分子检测。尽管形态学上有微小的重叠，但 SCTAT 和 AGCT 成分都具有相同的突变谱，包括 AGCT 特征性的 p.C134W 突变。因此，我们首次报告了具有 SCTAT 样形态的 AGCT。
