PhD Student, Department of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven; PhD Student, Eindhoven MedTech Innovation Center (e/MTIC), and Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven.
Gynecologist and PhD Student, Department of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven; Gynecologist and PhD Student, Eindhoven MedTech Innovation Center (e/MTIC), and Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven.
Obstet Gynecol Surv. 2020 Aug;75(8):497-509. doi: 10.1097/OGX.0000000000000811.
Hypertensive pregnancy disorders (HPDs) are associated with an increased risk of long-term cardiovascular disease. Speckle tracking echocardiography (STE) might be useful in the early detection of preclinical cardiac changes in women with HPDs.
The aim of this study was to study whether STE is a suitable method to detect differences in cardiac function in pregnant women with HPD compared with normotensive pregnant women or between women with a history of a pregnancy complicated by HPD compared with women with a history of an uncomplicated pregnancy.
The databases Medline, EMBASE, and Central were systematically searched for studies comparing cardiac function measured with STE in pregnant women with HPD or women with a history of HPD and women with a history of normotensive pregnancies.
The search identified 16 studies, including 870 women with a history of HPD and 693 normotensive controls. Most studies during pregnancy (n = 12/13) found a decreased LV-GLS (left ventricular global longitudinal strain) in HPD compared with normotensive pregnant controls. LV-GRS (left ventricular global radial strain) and LV-GLCS (left ventricular global circumferential strain) are decreased in women with early-onset and severe preeclampsia. Women with a history of early-onset preeclampsia show lasting myocardial changes, with significantly decreased LV-GLS, LV-GLCS, and LV-GRS.
LV-GLS is significantly decreased in pregnant women with HPD compared with normotensive pregnant women. Other deformation values show a significant decrease in women with severe or early-onset preeclampsia, with lasting myocardial changes after early-onset preeclampsia.
高血压妊娠疾病（HPD）与长期心血管疾病风险增加相关。斑点追踪超声心动图（STE）可能有助于早期发现 HPD 妇女的临床前心脏变化。
本研究旨在研究 STE 是否适合检测 HPD 孕妇与正常血压孕妇之间以及 HPD 病史孕妇与正常妊娠史孕妇之间的心脏功能差异。
系统检索了 Medline、EMBASE 和 Central 数据库，以寻找比较 HPD 孕妇或 HPD 病史孕妇与正常血压妊娠史孕妇的 STE 测量心脏功能的研究。
搜索确定了 16 项研究，包括 870 名 HPD 病史妇女和 693 名正常血压对照者。大多数妊娠期间的研究（n=12/13）发现 HPD 组的 LV-GLS（左心室整体纵向应变）较正常血压妊娠对照组降低。早发型和重度子痫前期妇女的 LV-GRS（左心室整体径向应变）和 LV-GLCS（左心室整体环向应变）降低。早发型子痫前期妇女存在持续的心肌变化，LV-GLS、LV-GLCS 和 LV-GRS 显著降低。
与正常血压妊娠妇女相比，HPD 孕妇的 LV-GLS 显著降低。其他变形值在重度或早发型子痫前期妇女中显著降低，早发型子痫前期后存在持续的心肌变化。
