Department of Basic Medical Sciences, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Asian Pac J Cancer Prev. 2020 Aug 1;21(8):2415-2421. doi: 10.31557/APJCP.2020.21.8.2415.
Transcription factor activating protein 2 B (TFAP2 B) is a transcription factor that regulates many steps of embryogenesis, cell growth, apoptosis and recently oncogenesis and cancer progression. AP-1 is a transcription factor that is a downstream molecule of the MAPK signaling pathway. Juxtaposed with zinc finger gene 1 (JAZF1) is a recently detected transforming growth factor which has a role in carcinogenesis. Hence the present study aimed to assess those markers expression in tissues from patients with such cancer correlation their expression with clinic-pathological findings of the tumor and prognostic and follow-up findings of patients.
We have collected tissue samples from papillary thyroid cancer patients and adjacent non-neoplastic tissues from 80 patients. We assessed the expression of TFAP2B, AP-1 and JAZF1 using immunohistochemistry.
Expression of TFAP2B was positively associated with lymph nodes metastases (p=0.003), distant metastases (p=0.002), recurrence of the tumor (p=0.002), unfavourable disease-free survival rate (p=0.003). AP-1 expression is positively associated with advanced stage (p=0.002), presence of extra-thyroid invasion (p=0.005), recurrence of the tumor (p=0.005), unfavorable disease-free survival rate (p=0.01). JAZF1 expression is negatively associated with huge tumor size (0.023), vascular invasion (p=0.007) and unfavorable overall survival rate (p=.030).
High expression levels of TFAP2B and AP-1 and low expression levels of JAZF1 were associated with unfavourable pathological, prognostic parameters and dismal patient's outcome.
.
转录因子激活蛋白 2B（TFAP2B）是一种转录因子，可调节胚胎发生、细胞生长、凋亡以及最近的致癌作用和癌症进展的多个步骤。AP-1 是 MAPK 信号通路的下游分子，是一种转录因子。锌指蛋白 1（JAZF1）是最近发现的一种转化生长因子，在致癌作用中具有一定作用。因此，本研究旨在评估这些标志物在癌症患者组织中的表达，并将其表达与肿瘤的临床病理发现及其与患者预后和随访的关系进行相关性分析。
方法：我们收集了 80 例甲状腺乳头状癌患者的组织样本及其相邻的非肿瘤组织样本。我们使用免疫组织化学法评估了 TFAP2B、AP-1 和 JAZF1 的表达。
结果：TFAP2B 的表达与淋巴结转移（p=0.003）、远处转移（p=0.002）、肿瘤复发（p=0.002）、不良无病生存率（p=0.003）呈正相关。AP-1 的表达与晚期分期（p=0.002）、甲状腺外侵犯（p=0.005）、肿瘤复发（p=0.005）、不良无病生存率（p=0.01）呈正相关。JAZF1 的表达与肿瘤体积大（0.023）、血管侵犯（p=0.007）和不良总生存率（p=0.030）呈负相关。
结论：TFAP2B 和 AP-1 的高表达水平以及 JAZF1 的低表达水平与不良的病理、预后参数和患者不良预后相关。
