妊娠和禁食对家兔肌肉葡萄糖利用的影响。

Effects of pregnancy and fasting on muscle glucose utilization in the rabbit.

作者信息

Hauguel S, Leturque A, Gilbert M, Girard J

机构信息

Centre de Recherche sur la Nutrition du CNRS, Meudon, France.

出版信息

Am J Obstet Gynecol. 1988 May;158(5):1215-8. doi: 10.1016/0002-9378(88)90257-8.

DOI:10.1016/0002-9378(88)90257-8

PMID:3285690

Abstract

The effects of fasting on maternal glucose metabolism were investigated in nonpregnant and 29-day pregnant conscious rabbits. Pregnancy decreased the glucose metabolic index by 60% in maternal red postural muscles. Fasting induced similar modifications in nonpregnant rabbits and exaggerated the changes observed in fed pregnant animals. These data suggest that the decreased glucose utilization by maternal red muscles observed during pregnancy and fasting is related to the increase in circulating fat-derived substrates, because the fall in plasma insulin concentration is a specific adaptation to fasting.

摘要

在未怀孕和怀孕29天的清醒兔子中研究了禁食对母体葡萄糖代谢的影响。怀孕使母体红色姿势肌中的葡萄糖代谢指数降低了60%。禁食在未怀孕的兔子中引起了类似的变化，并加剧了在进食的怀孕动物中观察到的变化。这些数据表明，在怀孕和禁食期间观察到的母体红色肌肉葡萄糖利用率降低与循环中脂肪衍生底物的增加有关，因为血浆胰岛素浓度的下降是对禁食的一种特定适应。