Lian E C
Division of Hematology, Veterans Administration Medical Center, Miami, Florida.
Annu Rev Med. 1988;39:203-12. doi: 10.1146/annurev.me.39.020188.001223.
Platelet thrombus formation in small vessels is triggered by certain stimuli, including vascular injury, primary platelet agglutination, or both. The formation and dissolution of platelet thrombi is modulated by proteolysis, plasma factors, PGI2 synthesis and stability, and immune mechanisms. Some recent evidence now suggests that there is a subset of thrombotic thrombocytopenic purpura (TTP) patients possessing a specific platelet agglutinating factor that triggers the intravascular platelet agglutination. Identification and classification of TTP patients into subgroups with common triggering agents, and further clarification of the role of modifying factors will enable us to understand the disease better and to improve therapy.
小血管中血小板血栓的形成由某些刺激引发，包括血管损伤、原发性血小板凝集或两者皆有。血小板血栓的形成和溶解受蛋白水解、血浆因子、前列环素（PGI2）合成与稳定性以及免疫机制的调节。最近的一些证据表明，有一部分血栓性血小板减少性紫癜（TTP）患者拥有一种特定的血小板凝集因子，可触发血管内血小板凝集。将TTP患者识别并分类为具有共同触发因素的亚组，并进一步阐明调节因素的作用，将使我们能更好地理解该疾病并改善治疗。
