Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
J Cell Biol. 2020 Sep 7;219(9). doi: 10.1083/jcb.202008031.
Mitophagy has a critical role in maintaining cellular homeostasis by removing damaged mitochondria. In this issue, Yamano et al. (2020. J. Cell Biol. https://doi.org/10.1083/jcb.201912144) uncover that a novel complex of the autophagy adaptor optineurin and the membrane protein ATG9A specifically regulate ubiquitin-induced mitophagy.
自噬在通过清除损伤的线粒体来维持细胞内稳态方面起着关键作用。在本期杂志中，Yamano 等人（2020. J. Cell Biol. https://doi.org/10.1083/jcb.201912144）揭示了一个由自噬衔接蛋白 optineurin 和膜蛋白 ATG9A 组成的新型复合物，可特异性调节泛素诱导的线粒体自噬。
