[前列腺素I2和E1对人主动脉培养平滑肌细胞胆固醇水平的影响]
[Effect of prostaglandins I2 and E1 on the cholesterol level in cultured smooth muscle cells from the human aorta].
作者信息
Shakhov Iu A, Lamaziere J M, Dorian B, Daret D, Larrue J
出版信息
Biokhimiia. 1988 Feb;53(2):328-31.
PMID:3285897
Abstract
Prostaglandins I2(PGI2) and E1(PGE1) (5 X 10(-7) M) reduced by 30% the content of intracellular cholesterol in cultured human aorta smooth muscle cells after 24 hrs of incubation in a medium without fetal calf serum. Total HDL, as well as HDL3 and HDL2b fractions stimulated the effect of prostaglandins on the reduction (by 50%) of cholesterol level.
摘要
在无胎牛血清的培养基中孵育24小时后，前列腺素I2（PGI2）和E1（PGE1）（5×10⁻⁷ M）可使培养的人主动脉平滑肌细胞内胆固醇含量降低30%。总高密度脂蛋白（HDL）以及HDL3和HDL2b组分可增强前列腺素对降低胆固醇水平（降低50%）的作用。
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