负协同性对海马CA1区兴奋性突触后电位长时程增强的抑制作用。
Inhibition of long-term potentiation of the hippocampal CA1 EPSP by a negative cooperativity.
作者信息
Xie X P
机构信息
Institute of Basic Medical Sciences, Beijing, People's Republic of China.
出版信息
Brain Res. 1988 Apr 5;445(2):367-9. doi: 10.1016/0006-8993(88)91201-2.
PMID:3285960
Abstract
Tetanization of commissural-CA1 input to the apical dendrites of the dorsal hippocampal CA1 area was found to produce a marked long-term potentiation of the field EPSP. Whereas by concurrent tetanization of the commissural pathway and medial septo-CA1 input, this potentiation was significantly reduced. Thus a negative cooperativity in LTP induction was revealed.
摘要
研究发现，对背侧海马CA1区顶端树突的联合- CA1输入进行强直刺激可产生显著的场兴奋性突触后电位（fEPSP）长时程增强。而通过同时对联合通路和内侧隔区- CA1输入进行强直刺激，这种增强作用则显著减弱。因此，揭示了长时程增强诱导中的负协同性。
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