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Implications of Withaferin A in neurological disorders.

作者信息

Ram Natasha, Peak Stephanie L, Perez Andres R, Jinwal Umesh K

机构信息

Department of Pharmaceutical Sciences, Taneja College of Pharmacy, University of South Florida, Tampa, FL, USA.

出版信息

Neural Regen Res. 2021 Feb;16(2):304-305. doi: 10.4103/1673-5374.290894.

DOI:10.4103/1673-5374.290894
PMID:32859786
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7896225/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5504/7896225/66238c908bac/NRR-16-304-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5504/7896225/66238c908bac/NRR-16-304-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5504/7896225/66238c908bac/NRR-16-304-g004.jpg

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Endoplasmic reticulum stress mediates withaferin A-induced apoptosis in human renal carcinoma cells.内质网应激介导知母宁 A 诱导人肾癌细胞凋亡。
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Astaxanthin and withaferin A block paracrine cytokine interactions between UVB-exposed human keratinocytes and human melanocytes via the attenuation of endothelin-1 secretion and its downstream intracellular signaling.虾青素和睡茄素A通过减弱内皮素-1分泌及其下游细胞内信号传导，阻断紫外线B照射的人角质形成细胞与人黑素细胞之间的旁分泌细胞因子相互作用。
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本文引用的文献

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Safety and pharmacokinetics of Withaferin-A in advanced stage high grade osteosarcoma: A phase I trial.维甲素-A在晚期高级别骨肉瘤中的安全性和药代动力学：一项I期试验。
J Ayurveda Integr Med. 2020 Jan-Mar;11(1):68-72. doi: 10.1016/j.jaim.2018.12.008. Epub 2019 Mar 21.
2
Ameliorative Effect of Withaferin A on Ageing-Mediated Impairment in the Dopamine System and Its Associated Behavior of Wistar Albino Rat.Withaferin A对Wistar白化大鼠多巴胺系统衰老介导损伤及其相关行为的改善作用
Pharmacology. 2019;103(3-4):114-119. doi: 10.1159/000495510. Epub 2018 Dec 13.
3
Withaferin A Suppresses Beta Amyloid in APP Expressing Cells: Studies for Tat and Cocaine Associated Neurological Dysfunctions.
睡茄内酯A抑制表达淀粉样前体蛋白细胞中的β淀粉样蛋白：对与塔他蛋白和可卡因相关的神经功能障碍的研究
Front Aging Neurosci. 2018 Sep 27;10:291. doi: 10.3389/fnagi.2018.00291. eCollection 2018.
4
Protection against cerebral infarction by Withaferin A involves inhibition of neuronal apoptosis, activation of PI3K/Akt signaling pathway, and reduced intimal hyperplasia via inhibition of VSMC migration and matrix metalloproteinases.Withaferin A对脑梗死的保护作用涉及抑制神经元凋亡、激活PI3K/Akt信号通路以及通过抑制血管平滑肌细胞迁移和基质金属蛋白酶来减少内膜增生。
Adv Med Sci. 2017 Mar;62(1):186-192. doi: 10.1016/j.advms.2016.09.003. Epub 2017 Mar 7.
5
Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis.反应性胶质增生的药理学抑制可阻断肿瘤坏死因子-α介导的神经元凋亡。
Cell Death Dis. 2016 Sep 29;7(9):e2386. doi: 10.1038/cddis.2016.277.
6
Treatment of adult and pediatric high-grade gliomas with Withaferin A: antitumor mechanisms and future perspectives.Withaferin A治疗成人和儿童高级别胶质瘤：抗肿瘤机制及未来展望。
J Nat Med. 2017 Jan;71(1):16-26. doi: 10.1007/s11418-016-1020-2. Epub 2016 Jul 2.
7
Exploring neuroprotective potential of Withania somnifera phytochemicals by inhibition of GluN2B-containing NMDA receptors: An in silico study.通过抑制含GluN2B的NMDA受体探索睡茄植物化学物质的神经保护潜力：一项计算机模拟研究。
Med Hypotheses. 2016 Jul;92:35-43. doi: 10.1016/j.mehy.2016.04.034. Epub 2016 Apr 20.
8
Identification and quantitative analysis of cellular proteins affected by treatment with withaferin a using a SILAC-based proteomics approach.使用基于稳定同位素标记氨基酸的细胞培养（SILAC）的蛋白质组学方法对受睡茄内酯a处理影响的细胞蛋白质进行鉴定和定量分析。
J Ethnopharmacol. 2015 Dec 4;175:86-92. doi: 10.1016/j.jep.2015.09.024. Epub 2015 Sep 24.
9
Pharmacologic overview of Withania somnifera, the Indian Ginseng.印度人参睡茄的药理学概述。
Cell Mol Life Sci. 2015 Dec;72(23):4445-60. doi: 10.1007/s00018-015-2012-1. Epub 2015 Aug 26.
10
Withaferin A Regulates LRRK2 Levels by Interfering with the Hsp90- Cdc37 Chaperone Complex.牛膝甾酮A通过干扰热休克蛋白90-细胞分裂周期蛋白37伴侣复合物来调节富含亮氨酸重复激酶2（LRRK2）的水平。
Curr Aging Sci. 2015;8(3):259-65. doi: 10.2174/1874609808666150520111109.