母亲高血压疾病与新生儿先天性心脏病的关联：一项美国队列研究分析。
The association of maternal hypertensive disorders with neonatal congenital heart disease: analysis of a United States cohort.
机构信息
Women's Medicine Collaborative-Division of Research, The Miriam Hospital, Providence, RI, USA.
Division of Fetal and Translational Medicine, Children's National Hospital, Washington, DC, USA.
出版信息
J Perinatol. 2020 Nov;40(11):1617-1624. doi: 10.1038/s41372-020-00795-9. Epub 2020 Aug 28.
OBJECTIVE
To examine the association of any type of maternal hypertensive disorders of pregnancy (HDP) and neonatal congenital heart diseases (CHD).
STUDY DESIGN
We compared the prevalence of CHD between neonates born to mothers with HDP to those delivered to mothers without HDP among 24,525,889 hospital records of living infants, from a national database. We controlled for multiple confounding factors by using multiple logistic regression analysis.
RESULTS
Infants delivered to mothers with HDP had higher prevalence of CHD compared to infants born to mothers without HDP [5.20% vs. 1.47%; aOR: 2.51(2.38-2.64), p < 0.001]. Maternal diabetes was more frequent among infants born to mothers with HDP and was independently associated with CHD [aOR 5.14 (5.04-5.23), p < 0.001].
CONCLUSION
Infants born to mothers with hypertension had almost a threefold increase in CHD compared with those born to mothers without hypertension. Further studies are needed to investigate the underlying mechanism and direction of this association.
目的
探讨妊娠高血压疾病（HDP）的任何类型与新生儿先天性心脏病（CHD）的关联。
研究设计
我们比较了来自全国数据库的 24525899 例活产婴儿的母亲患有 HDP 与未患 HDP 的新生儿 CHD 的患病率。我们通过多因素逻辑回归分析控制了多个混杂因素。
结果
与母亲未患 HDP 的新生儿相比，患有 HDP 的母亲所生婴儿的 CHD 患病率更高[5.20%比 1.47%；优势比：2.51（2.38-2.64），p<0.001]。患有 HDP 的母亲中，糖尿病更为常见，且与 CHD 独立相关[优势比 5.14（5.04-5.23），p<0.001]。
结论
与母亲无高血压的新生儿相比，患有高血压的母亲所生婴儿的 CHD 风险增加近三倍。需要进一步研究以探讨这种关联的潜在机制和方向。
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