胃旁路手术后的骨密度、甲状旁腺激素和维生素 D：长达 10 年的纵向随访。
Bone Mineral Density, Parathyroid Hormone, and Vitamin D After Gastric Bypass Surgery: a 10-Year Longitudinal Follow-Up.
机构信息
Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Department of Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
出版信息
Obes Surg. 2020 Dec;30(12):4995-5000. doi: 10.1007/s11695-020-04912-7. Epub 2020 Aug 28.
BACKGROUND
The aim of the present study was to study longitudinal changes in bone mineral density (BMD), vitamin D, and parathyroid hormone (PTH) levels in females over a 10-year period after laparoscopic Roux-en-Y gastric bypass (LRYGB).
METHODS
Twenty-three women, mean age 43.4 ± 8.7 years and mean body mass index (BMI) 44.6 ± 5.17 kg/m at baseline, were included. BMD, BMI, S-calcium, S-25(OH)-vitamin D, and fP-PTH were measured preoperatively and 2, 5, and 10 years postoperatively.
RESULTS
Ten years after surgery, BMD of the spine and femoral neck decreased by 20% and 25%, respectively. Changes in serum levels of vitamin D, PTH, and calcium over the same period were small.
CONCLUSION
After LRYGB with subsequent massive weight loss, a large decrease in BMD of the spine and femoral neck was seen over a 10-year postoperative period. The fall in BMD largely occurred over the first 5 years after surgery.
背景
本研究旨在研究女性在腹腔镜 Roux-en-Y 胃旁路术（LRYGB）后 10 年内骨密度（BMD）、维生素 D 和甲状旁腺激素（PTH）水平的纵向变化。
方法
23 名女性，平均年龄 43.4±8.7 岁，基线时平均体重指数（BMI）为 44.6±5.17kg/m2，纳入本研究。在术前和术后 2、5 和 10 年时测量 BMD、BMI、S-钙、S-25（OH）-维生素 D 和 fP-PTH。
结果
手术后 10 年，脊柱和股骨颈的 BMD 分别下降了 20%和 25%。同期血清维生素 D、PTH 和钙水平的变化较小。
结论
LRYGB 术后大量体重减轻后，在 10 年的术后期间，脊柱和股骨颈的 BMD 大量下降。BMD 的下降主要发生在术后 5 年内。
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