Department of Rheumatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, PR China.
Chongqing Key Laboratory of Traditional Chinese Medicine to Prevent and Treat Autoimmune Diseases, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, 400021, PR China; Basic Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, 611137, PR China.
Biomed Pharmacother. 2020 Nov;131:110675. doi: 10.1016/j.biopha.2020.110675. Epub 2020 Aug 28.
Icariin has a variety of biological activities, such as lipid-lowering effects, and has attracted widespread attention in recent years. However, it is not clear whether lipid-lowering effect is that multiple metabolites or a particular component plays a major role. It is known that icariin has a variety of metabolites in the body, including icariside I, icariside II, icaritin, desmethylicaritin, and other metabolites. Many of these studies have shown that the metabolites of icariin have a lipid-lowering effect. This paper focuses on the lipid-regulating effects of icariin and its metabolites in vitro and in vivo, and highlights the mechanisms involved. Icariin may have potential in the development of therapeutic strategies to regulate lipid metabolism.
朝藿定具有多种生物学活性，如降脂作用，近年来受到广泛关注。然而，尚不清楚降脂作用是由多种代谢物还是特定成分起主要作用。已知朝藿定在体内有多种代谢物，包括朝藿苷 I、朝藿苷 II、淫羊藿苷、去甲淫羊藿苷等代谢物。许多研究表明，朝藿定的代谢物具有降脂作用。本文重点介绍了朝藿定及其代谢物在体外和体内的调脂作用，并强调了相关机制。朝藿定可能在开发调节脂质代谢的治疗策略方面具有潜力。
