Hematology Mayo Clinic Rochester, Mayo Clinic Alix School of Medicine, Mayo Clinic Cancer Center, 200 Southwest 1st Street, Rochester, MN 55905, USA.
Hematol Oncol Clin North Am. 2020 Oct;34(5):825-835. doi: 10.1016/j.hoc.2020.06.001. Epub 2020 Jul 26.
Mantle cell lymphoma, despite its common derivation from a t(11;14) error that occurs in a naïve B-cell leading to overexpression of cyclin D1 protein, is characterized by substantial heterogeneity in biology and clinical outcome. Unlike other non-Hodgkin lymphoma types, it is more common in men. Clinical presentation patterns vary from nodal to splenomegaly with leukemia to gastrointestinal involvement. Biological variability is linked to tumor cell proliferation. Increased monocyte/macrophages and their associated proinflammatory cytokines are associated with inferior outcomes. These clues mandate that new treatments should target signal pathways that contribute to these adverse outcomes.
套细胞淋巴瘤，尽管其通常起源于幼稚 B 细胞发生的 t(11;14)错误，导致 cyclin D1 蛋白过表达，但在生物学和临床结局方面具有显著的异质性。与其他非霍奇金淋巴瘤类型不同，它在男性中更为常见。临床表现模式从淋巴结到脾肿大伴白血病到胃肠道受累不等。生物学变异性与肿瘤细胞增殖有关。增加的单核细胞/巨噬细胞及其相关的促炎细胞因子与不良结局相关。这些线索表明，新的治疗方法应该针对导致这些不良结局的信号通路。
