School of Life Sciences, Pharmacy and Chemistry, Kingston University London, Penrhyn Road, Kingston upon Thames, KT1 2EE, UK.
School of Life Sciences, Pharmacy and Chemistry, Kingston University London, Penrhyn Road, Kingston upon Thames, KT1 2EE, UK.
Trends Pharmacol Sci. 2020 Oct;41(10):686-689. doi: 10.1016/j.tips.2020.07.005. Epub 2020 Aug 26.
Oral administration of drugs is one of the most patient-friendly drug delivery routes. However, drug bioavailability via the oral route remains poor due to the harsh gastrointestinal environment. In recent years, many nanocarriers have been designed to overcome this limitation. Among those, chitosan nanoparticles (ChNPs) have proved to be a quite popular choice. Here, we highlight the use of fluorescein isothiocyanate-tagged ChNPs as an invaluable tool to monitor the fate of ChNPs encapsulating oral drugs, leading to an in-depth understanding of drug biodistribution and, in turn, shedding light on ways to improve bioavailability.
口服给药是最受患者欢迎的药物递送途径之一。然而，由于胃肠道环境恶劣，药物经口服途径的生物利用度仍然很差。近年来，许多纳米载体被设计用来克服这一限制。其中，壳聚糖纳米颗粒（ChNPs）已被证明是一种非常受欢迎的选择。在这里，我们强调使用异硫氰酸荧光素标记的 ChNPs 作为监测包裹口服药物的 ChNPs 命运的宝贵工具，从而深入了解药物的生物分布，并由此揭示提高生物利用度的方法。
