A. E. Caprifico, Dr. E. Polycarpou, Prof. P. J. S. Foot, Dr. G. Calabrese, Pharmacy and Chemistry, Kingston University London, Penrhyn Road, Kingston upon Thames, KT1 2EE, UK.
Macromol Biosci. 2021 Jan;21(1):e2000312. doi: 10.1002/mabi.202000312. Epub 2020 Oct 4.
Chitosan-based nanocarriers (ChNCs) are considered suitable drug carriers due to their ability to encapsulate a variety of drugs and cross biological barriers to deliver the cargo to their target site. Fluorescein isothiocyanate-labeled chitosan-based NCs (FITC@ChNCs) are used extensively in biomedical and pharmacological applications. The main advantage of using FITC@ChNCs consists of the ability to track their fate both intra and extracellularly. This journey is strictly dependent on the physico-chemical properties of the carrier and the cell types under investigation. Other applications make use of fluorescent ChNCs in cell labeling for the detection of disorders in vivo and controlling of living cells in situ. This review describes the use of FITC@ChNCs in the various applications with a focus on understanding their usefulness in labeled drug-delivery systems.
基于壳聚糖的纳米载体（ChNCs）由于能够包裹各种药物并穿越生物屏障将货物递送到靶部位，被认为是合适的药物载体。荧光素异硫氰酸酯标记的基于壳聚糖的 NCs（FITC@ChNCs）在生物医学和药理学应用中得到了广泛的应用。使用 FITC@ChNCs 的主要优点在于能够在细胞内外跟踪它们的命运。这种传递过程严格依赖于载体的物理化学性质和被研究的细胞类型。其他应用还利用荧光 ChNCs 对细胞进行标记，以检测体内的疾病并原位控制活细胞。本文综述了 FITC@ChNCs 在各种应用中的使用情况，重点探讨了它们在标记药物传递系统中的应用价值。
