Yonetani Shota, Araki Koji, Nishi Yoshifumi, Kurai Daisuke, Ohnishi Hiroaki
Department of Medical Technology Faculty of Health Sciences, Kyorin University, Tokyo, Japan; Department of Clinical Laboratory Kyorin University School of Medicine, Tokyo, Japan.
Department of Clinical Laboratory Kyorin University School of Medicine, Tokyo, Japan.
J Infect Chemother. 2021 Jan;27(1):83-85. doi: 10.1016/j.jiac.2020.08.013. Epub 2020 Aug 27.
"Neisseria skkuensis" is a gram-negative coccus that is endemic in the human oral cavity, with only few reports of infection in humans. Herein, we report a case of a male patient in his sixties presenting with infective endocarditis (IE) caused by "N. skkuensis". To our knowledge, this is the second case of IE confirmed using 16S rRNA gene to have been caused by "N. skkuensis". The accurate diagnosis of rare or difficult-to-identify pathogens is a major challenge for clinical microbiological laboratories. Although Neisseria spp. are common in the oral cavity and are often seen in routine tests, identification of their biochemical properties and mass spectrometric analysis are difficult. In this case report, we describe the accurate identification of "N. skkuensis" by 16S rRNA gene sequencing analysis compared to other identification methods. Further cases of "N. skkuensis" are needed to fully evaluate the clinical approach of this detection method.
“庆熙奈瑟菌”是一种革兰氏阴性球菌，在人类口腔中呈地方性流行，人类感染报告极少。在此，我们报告一例60多岁男性患者，患有由“庆熙奈瑟菌”引起的感染性心内膜炎（IE）。据我们所知，这是第二例经16S rRNA基因确认由“庆熙奈瑟菌”引起的IE病例。准确诊断罕见或难以鉴定的病原体是临床微生物实验室面临的一项重大挑战。虽然奈瑟菌属在口腔中很常见，且在常规检测中经常出现，但其生化特性鉴定和质谱分析都很困难。在本病例报告中，我们描述了通过16S rRNA基因测序分析与其他鉴定方法相比，对“庆熙奈瑟菌”的准确鉴定。需要更多“庆熙奈瑟菌”病例来全面评估这种检测方法的临床应用。
