Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Department of Orthopaedics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Trends Cell Biol. 2020 Oct;30(10):752-763. doi: 10.1016/j.tcb.2020.07.006. Epub 2020 Aug 26.
Hematopoiesis generally refers to hematopoietic development in fetuses and adults, as well as to hematopoietic stem cell differentiation into progeny lineages. The multiple processes that generate diverse hematopoietic cells have been considered to be unidirectional. However, many reports have recently demonstrated that these processes are not only reversible but also interconvertible via cell reprogramming. The cell reprogramming that occurs in hematopoietic cells is termed hematopoietic reprogramming. We focus on both autogenous and artificial hematopoietic reprogramming under physiological and pathological conditions that is mainly directed by the actions of transcription factors (TFs), chemical compounds, or extracellular cytokines. A comprehensive understanding of hematopoietic reprogramming will help us not only to generate desirable cells for cell therapy but also to further analyze normal and malignant hematopoiesis.
造血通常是指胎儿和成人的造血发育，以及造血干细胞向祖细胞谱系的分化。产生各种造血细胞的多个过程被认为是单向的。然而，最近有许多报道表明，这些过程不仅是可逆的，而且可以通过细胞重编程相互转换。造血细胞中发生的细胞重编程称为造血重编程。我们主要关注生理和病理条件下的自体和人工造血重编程，这些重编程主要由转录因子（TFs）、化学化合物或细胞外细胞因子的作用来指导。全面了解造血重编程不仅有助于我们生成用于细胞治疗的理想细胞，还有助于我们进一步分析正常和恶性造血。
