Kerner W, Brückel J, Zier H, Arias P, Thun C, Moncayo R, Pfeiffer E F
Department of Internal Medicine I, University of Ulm, F.R.G.
Diabetes Res Clin Pract. 1988 Apr 6;4(4):269-74. doi: 10.1016/s0168-8227(88)80028-7.
Effects of constant and pulsatile i.v. insulin delivery were examined in seven healthy subjects by means of euglycemic clamp technique. Each subject received constant insulin infusion (0.175 mU/kg.min) or insulin pulses at 12-min intervals (2.1 mU/kg) in randomized order for 8-h periods (08.00-16.00 h). Endogenous secretion of insulin was inhibited by concomitant administration of somatostatin (300 micrograms/h). Serum insulin concentrations during constant infusion (12 +/- 1 microU/ml) did not differ from basal values (11 +/- 1 microU/ml). Pulsatile insulin delivery resulted in oscillations of mean concentrations between values of about 10 and 20 microU/ml. Mean blood glucose concentrations during experiments were kept at 80 +/- 1 mg/dl, irrespective of the mode of insulin administration. Moreover, dextrose requirements for maintenance of these glucose concentrations did not differ over the hole periods of examination. We conclude that effects of constant and pulsatile delivery of basal amounts of insulin are not different. This at least applies to peripheral, short-term insulin administration in somatostatin-treated normal man, during an euglycemic clamp.
采用正常血糖钳夹技术，在7名健康受试者中研究了持续静脉输注胰岛素和脉冲式静脉输注胰岛素的效果。每位受试者按随机顺序接受持续胰岛素输注（0.175 mU/kg·min）或每12分钟一次的胰岛素脉冲输注（2.1 mU/kg），持续8小时（08:00 - 16:00）。同时给予生长抑素（300微克/小时）以抑制胰岛素的内源性分泌。持续输注期间的血清胰岛素浓度（12±1微单位/毫升）与基础值（11±1微单位/毫升）无差异。脉冲式胰岛素输注导致平均浓度在约10至20微单位/毫升之间波动。实验期间的平均血糖浓度保持在80±1毫克/分升，与胰岛素给药方式无关。此外，维持这些血糖浓度所需的葡萄糖量在整个检查期间没有差异。我们得出结论，基础量胰岛素的持续输注和脉冲式输注效果无差异。这至少适用于在正常血糖钳夹期间，对接受生长抑素治疗的正常男性进行外周短期胰岛素给药的情况。
