Sorbonne Université, CNRS, UMR8226, Institut de Biologie Physico-Chimique, Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes, F-75005 Paris, France.
Sorbonne Université, CNRS, UMR8226, Institut de Biologie Physico-Chimique, Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes, F-75005 Paris, France.
Biochim Biophys Acta Bioenerg. 2020 Dec 1;1861(12):148302. doi: 10.1016/j.bbabio.2020.148302. Epub 2020 Aug 27.
From mitochondrial quality control pathways to the regulation of specific functions, the Ubiquitin Proteasome System (UPS) could be compared to a Swiss knife without which mitochondria could not maintain its integrity in the cell. Here, we review the mechanisms that the UPS employs to regulate mitochondrial function and efficiency. For this purpose, we depict how Ubiquitin and the Proteasome participate in diverse quality control pathways that safeguard entry into the mitochondrial compartment. A focus is then achieved on the UPS-mediated control of the yeast mitofusin Fzo1 which provides insights into the complex regulation of this particular protein in mitochondrial fusion. We ultimately dissect the mechanisms by which the UPS controls the degradation of mitochondria by autophagy in both mammalian and yeast systems. This organization should offer a useful overview of this abundant but fascinating literature on the crosstalks between mitochondria and the UPS.
从线粒体质量控制途径到特定功能的调节，泛素蛋白酶体系统 (UPS) 可以比作一把瑞士军刀，如果没有它，线粒体就无法在细胞中保持其完整性。在这里，我们回顾了 UPS 用来调节线粒体功能和效率的机制。为此，我们描述了泛素和蛋白酶体如何参与多种质量控制途径，以保护线粒体进入线粒体隔室。然后，我们将重点放在 UPS 介导的酵母融合所需的线粒体融合蛋白 Fzo1 的控制上，这为该特定蛋白质在线粒体融合中的复杂调节提供了深入的了解。我们最终剖析了 UPS 通过哺乳动物和酵母系统中的自噬来控制线粒体降解的机制。这种组织方式应该为线粒体和 UPS 之间的串扰的丰富但迷人的文献提供有用的概述。
