O'Leary Bobby D, Armstrong Fionnvola M, Byrne Sally, Talento Alida Fe, O'Coigligh Seosamh
Department of Obstetrics and Gynaecology, Our Lady of Lourdes Hospital, Drogheda, Co. Louth, Ireland.
Department of Obstetrics and Gynaecology, Our Lady of Lourdes Hospital, Drogheda, Co. Louth, Ireland.
Eur J Obstet Gynecol Reprod Biol. 2020 Oct;253:103-107. doi: 10.1016/j.ejogrb.2020.08.004. Epub 2020 Aug 23.
Pregnancy induces unique physiological changes to the urinary tract, leaving pregnant women more susceptible to pyelonephritis. Urinary tract infections are generally diagnosed using urine sampling and testing with reagent sticks (dipstick) or laboratory culture. This study aimed to establish the prevalence of positive urine reagent strip and urine culture in asymptomatic pregnant women.
This was a cross-sectional study of 300 women attending routine antenatal clinics. Samples were analysed using an automated urine dipstick analyser for the presence of glucose, protein, leucocyte esterase, blood, and nitrites. All samples were cultured. Multinomial logistic regression was performed to investigate risk factors for urine contamination and infection. Sensitivities and specificities were calculated for common dipstick findings for positive and mixed urine culture.
One-in-three (37.0 % [111/300], 95 % CI 31.6-42.8 %) women had at least one positive finding on reagent strip testing. Ten per cent ([29/300], 95 % CI 6.7-13.7 %) of samples had a positive culture for a single organism, whereas 46.7 % ([140/300], 95 % CI 40.9-52.5 %) of samples were positive for multiple organisms (mixed culture). 43.7 % ([131/300], 95 % CI 38.0-49.5 %) of samples had a negative culture. Organisms cultured were similar to previous reports from high-income countries. BMI was identified on regression analysis as a risk factor for contamination.
There is a high prevalence of positive urine dipstick and contaminated culture in asymptomatic pregnant women. BMI is a risk factor for urine culture contamination and further research into this topic is essential given trends in obesity worldwide.
妊娠会引起泌尿道独特的生理变化，使孕妇更容易患肾盂肾炎。尿路感染通常通过尿液采样并用试剂条（试纸）或实验室培养进行检测。本研究旨在确定无症状孕妇尿试剂条阳性和尿培养阳性的患病率。
这是一项对300名到常规产前诊所就诊的女性进行的横断面研究。使用自动尿试纸分析仪分析样本中是否存在葡萄糖、蛋白质、白细胞酯酶、血液和亚硝酸盐。所有样本均进行培养。进行多项逻辑回归以研究尿液污染和感染的危险因素。计算了尿试纸常见阳性结果与混合尿培养的敏感性和特异性。
三分之一（37.0%[111/300]，95%可信区间31.6 - 42.8%）的女性在试纸检测中至少有一项阳性结果。10%（[29/300]，95%可信区间6.7 - 13.7%）的样本单一微生物培养呈阳性，而46.7%（[140/300]，95%可信区间40.9 - 52.5%）的样本多种微生物呈阳性（混合培养）。43.7%（[131/300]，95%可信区间38.0 - 49.5%）的样本培养结果为阴性。培养出的微生物与高收入国家先前的报告相似。回归分析确定体重指数是污染的一个危险因素。
无症状孕妇尿试纸阳性和培养污染的患病率很高。体重指数是尿培养污染的一个危险因素，鉴于全球肥胖趋势，对这一主题进行进一步研究至关重要。
