Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Victoria, Australia; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia; Department of Molecular and Translational Science, Monash University, Clayton, Victoria, Australia.
Curr Opin Microbiol. 2021 Feb;59:58-64. doi: 10.1016/j.mib.2020.07.015. Epub 2020 Aug 27.
Many Gram-negative enteric pathogens, including enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC), Salmonella, Shigella, and Yersinia species have evolved strategies to combat host defence mechanisms. Critical bacterial virulence factors, which often include but are not limited to type III secreted effector proteins, are deployed to cooperatively interfere with key host defence pathways. Recent studies in this area have not only contributed to our knowledge of bacterial pathogenesis, but have also shed light on the host pathways that are critical for controlling bacterial infection. In this review, we summarise recent breakthroughs in our understanding of the mechanisms utilised by enteric bacterial pathogens to rewire critical host innate immune responses, including cell death and inflammatory signaling and cell-intrinsic anti-microbial responses such as xenophagy.
许多革兰氏阴性肠道病原体，包括肠致病性和肠出血性大肠杆菌（EPEC 和 EHEC）、沙门氏菌、志贺氏菌和耶尔森氏菌，已经进化出了对抗宿主防御机制的策略。关键的细菌毒力因子，通常包括但不限于 III 型分泌效应蛋白，被用来协同干扰关键的宿主防御途径。这一领域的最新研究不仅增进了我们对细菌发病机制的了解，还揭示了宿主途径对于控制细菌感染的重要性。在这篇综述中，我们总结了近年来我们对肠道细菌病原体利用的机制的理解的突破，这些机制包括重新布线关键的宿主先天免疫反应，包括细胞死亡和炎症信号以及细胞内抗微生物反应，如异噬作用。
