de Vos Chloé, Leopold Karolina, Blanke Elisabeth S, Siebert Stefan, Baumgardt Johanna, Burkhardt Eva, Bechdolf Andreas
Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Vivantes Hospital Am Urban and Vivantes Hospital Im Friedrichshain, Charité-Universitätsmedizin Berlin, Germany; Department of Psychiatry and Psychotherapy, University Hospital Cologne, Germany.
Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Vivantes Hospital Am Urban and Vivantes Hospital Im Friedrichshain, Charité-Universitätsmedizin Berlin, Germany.
Psychiatry Res. 2020 Nov;293:113424. doi: 10.1016/j.psychres.2020.113424. Epub 2020 Aug 23.
Cannabis use is highly prevalent among young people diagnosed with first-episode psychosis (FEP), however, its impact on cognition is still unclear. The aim of the present study was to examine the association of cannabis use with cognition in people diagnosed with FEP. We extended previous research findings by operationalising the comorbid cannabis use, considering recency of cannabis use and use of other illicit substances and including people with a broad spectrum of psychotic diagnoses. A total of 89 people diagnosed with FEP were interviewed about their history of substance use and completed a cognitive test battery assessing verbal memory, verbal fluency and attention. Sixty-one participants were lifetime cannabis users (CU; ≥three times per week for ≥four weeks; 68.5%) and 28 were cannabis non-users (CNU; 31.5%). CU were significantly more likely to be male and exhibited significantly more positive symptoms than CNU. In contrast, CNU displayed significantly more negative symptoms than CU. There were no differences between CU and CNU on neurocognitive tasks of verbal memory, verbal fluency and attention. In conclusion, there was no indication that cannabis use was associated with cognitive impairments in people diagnosed with FEP.
在首次发作精神病（FEP）患者中，大麻使用非常普遍，然而，其对认知的影响仍不明确。本研究的目的是探讨大麻使用与FEP患者认知之间的关联。我们通过对合并大麻使用进行操作化、考虑大麻使用的近期情况以及其他非法物质的使用，并纳入广泛精神病诊断的患者，扩展了先前的研究结果。共对89名FEP患者进行了物质使用史访谈，并完成了一组评估言语记忆、言语流畅性和注意力的认知测试。61名参与者为终身大麻使用者（CU；每周≥三次，持续≥四周；68.5%），28名参与者为非大麻使用者（CNU；31.5%）。CU男性比例显著更高，且与CNU相比，表现出显著更多的阳性症状。相反，CNU比CU表现出显著更多的阴性症状。在言语记忆、言语流畅性和注意力的神经认知任务方面，CU和CNU之间没有差异。总之，没有迹象表明大麻使用与FEP患者的认知障碍有关。
