Lan Kuo-Chung, Chiang Hsin-Ju, Huang Tiao-Lai, Chiou Yu-Jie, Hsu Te-Yao, Ou Yu-Che, Yang Yao-Hsu
Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung City, Taiwan.
Center for Menopause and Reproductive Medicine Research, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
J Assist Reprod Genet. 2021 Jan;38(1):85-93. doi: 10.1007/s10815-020-01936-x. Epub 2020 Aug 30.
To study the association between paternal age and schizophrenia in offspring.
This report describes a nationwide population-based cohort study from 1997 to 2013. Data from Taiwan's National Health Insurance Research Database were utilized to answer the research question. A total of 17,649 offspring with schizophrenia were selected from 11 million offspring in the general population. Additionally, we established the offspring without schizophrenia as the comparison group by matching the study cohort by age, gender in a 1:4 ratio (n = 70,596).
The median age at first presentation with schizophrenia was 20 years (interquartile range (IQR), 17 to 24). Comparison of the schizophrenia and non-schizophrenia groups indicated that father's age at birth (30.0 (IQR), 27 to 33 vs. 29.0 (IQR), 26 to 32 years), mother's age at birth (26.0 (IQR), 24 to 29 vs. 26.0 (IQR), 23 to 29 years), paternal schizophrenia (2.6% vs. 0.6%), and maternal schizophrenia (4.4% vs. 0.7%) were all significantly greater in the schizophrenia group. In addition, each 5-year increase in father's age increased the odds of being diagnosed with schizophrenia (model 1: aOR = 1.22; 95% CI 1.20, 1.24; model 2: aOR = 1.20; 95% CI 1.18, 1.23). Subgroup analysis showed that each 5-year increase in father's age increased the odds of being diagnosed with schizophrenia in male and female offspring, as well as in offspring of mothers and fathers with or without schizophrenia (aOR = 1.20 to 2.20, all p values < 0.01).
This study indicated that advanced paternal age increased the risk of schizophrenia in offspring. Offspring born to fathers older by 5-year increments were at heightened risk of schizophrenia.
研究父亲年龄与子代精神分裂症之间的关联。
本报告描述了一项1997年至2013年基于全国人群的队列研究。利用台湾国民健康保险研究数据库的数据来回答研究问题。从普通人群的1100万子代中选取了17649例患有精神分裂症的子代。此外，我们通过按年龄、性别以1:4的比例匹配研究队列（n = 70596），设立了无精神分裂症的子代作为对照组。
首次出现精神分裂症症状的中位年龄为20岁（四分位间距（IQR），17至24岁）。精神分裂症组与非精神分裂症组的比较表明，精神分裂症组父亲的出生年龄（30.0（IQR），27至33岁 vs. 29.0（IQR），26至32岁）、母亲的出生年龄（26.0（IQR），24至29岁 vs. 26.0（IQR），23至29岁）、父亲患精神分裂症的比例（2.6% vs. 0.6%）以及母亲患精神分裂症的比例（4.4% vs. 0.7%）均显著更高。此外，父亲年龄每增加5岁，被诊断为精神分裂症的几率就会增加（模型1：调整后比值比（aOR）= 1.22；95%置信区间（CI）1.20，1.24；模型2：aOR = 1.20；95% CI 1.18，1.23）。亚组分析表明，父亲年龄每增加5岁，男性和女性子代以及父母患有或未患有精神分裂症的子代被诊断为精神分裂症的几率都会增加（aOR = 1.20至2.20，所有p值<0.01）。
本研究表明父亲年龄较大增加了子代患精神分裂症的风险。父亲年龄每增加5岁出生的子代患精神分裂症的风险更高。
