Institute of Evidence Law and Forensic Science, China University of Political Science and Law (CUPL), Key Laboratory of Evidence Law and Forensic Science, Ministry of Education, Beijing, 100088, China.
University Center of Legal Medicine, Lausanne-Geneva (CURML), Lausanne, CH1000, Switzerland.
Curr Med Sci. 2020 Aug;40(4):786-794. doi: 10.1007/s11596-020-2244-7. Epub 2020 Aug 29.
Choosing proper perfusates as contrast agents is an important aspect for postmortem magnetic resonance angiography (PMMRA). However, in this emerging field, the number of suitable kinds of liquid is still very limited. The objective of this research is to compare MR images of oleic acid (OA) with paraffin oil (PO) in vitro and in ex situ animal hearts, in order to evaluate the feasibility to use OA as a novel contrast agent for PMMRA. In vitro, OA, PO and water (control) were introduced into three tubes separately and Tweighted-spin echo (Tw-SE) and Tw-SE images were acquired on a 1.5T MR scanner. In the second experiment, OA and PO were injected into left coronary artery (LCA) and left ventricle (LV) of ex situ bovine hearts and their Tw-SE, Tw-SE, Tw-multipoint Dixon (Tw-mDixon) and 3DTw-mDixon images were acquired. The overall results indicate that OA may have a potential to be used as a dual (T and T based) contrast agent for PMMRA when proper sequence parameters are utilized. However, as the pilot study was based on limited number of animal hearts, more researches using OA in cadavers are needed to validate our findings.
选择合适的灌注液作为对比剂是法医磁共振血管造影术（PMRA）的一个重要方面。然而，在这个新兴领域，合适的液体种类仍然非常有限。本研究的目的是比较油酸（OA）和石蜡油（PO）在体外和离体动物心脏中的磁共振图像，以评估 OA 作为 PMMRA 新型对比剂的可行性。在体外，OA、PO 和水（对照）分别注入三个管中，并在 1.5T MR 扫描仪上采集 T 加权自旋回波（Tw-SE）和 Tw-SE 图像。在第二个实验中，OA 和 PO 被注入离体牛心的左冠状动脉（LCA）和左心室（LV），并采集其 Tw-SE、Tw-SE、Tw 多点 Dixon（Tw-mDixon）和 3DTw-mDixon 图像。总体结果表明，当使用适当的序列参数时，OA 可能有潜力成为 PMMRA 的双（T 和 T 基）对比剂。然而，由于该初步研究基于有限数量的动物心脏，需要使用 OA 在尸体中进行更多的研究来验证我们的发现。
