Robba C, Rebuffat P, Mazzocchi G, Nussdorfer G G
Department of Anatomy, University of Padua/Italy.
Exp Clin Endocrinol. 1988 Mar;91(1):51-8. doi: 10.1055/s-0029-1210721.
The effects of chronic administration of metoclopramide or bromocriptine (two drugs which act as antagonist and agonist of dopamine receptors) on the zona glomerulosa of captopril-treated rats administered maintenance doses of angiotensin II, were investigated by combined morphometric and biochemical techniques. It was found that metoclopramide provoked a significant hypertrophy of the zona glomerulosa and its parenchymal cells, coupled with a persistent rise in the plasma concentration of aldosterone, only in rats fed a normal diet. Conversely, bromocriptine exerted an evident inhibitory effect on the zona glomerulosa growth and steroidogenic capacity only in chronically sodium-deprived animals. These findings strongly suggest that sodium balance modulates the activity of the dopaminergic system, whose chronic suppression may be involved in the mechanism underlying the extra-angiotensin adrenoglomerulotrophic effect of prolonged sodium restriction.
采用形态计量学和生化技术相结合的方法，研究了长期给予甲氧氯普胺或溴隐亭（两种分别作为多巴胺受体拮抗剂和激动剂的药物）对接受血管紧张素II维持剂量治疗的卡托普利处理大鼠的肾小球带的影响。结果发现，仅在喂食正常饮食的大鼠中，甲氧氯普胺会引起肾小球带及其实质细胞显著肥大，同时醛固酮血浆浓度持续升高。相反，溴隐亭仅在长期缺钠的动物中对肾小球带的生长和类固醇生成能力产生明显的抑制作用。这些发现强烈表明，钠平衡调节多巴胺能系统的活性，长期限制钠摄入时，多巴胺能系统的慢性抑制可能参与了血管紧张素外肾上腺球旁营养作用的潜在机制。
