Memorial Sloan Kettering Cancer and Weill Cornell Medical College, New York, NY, USA.
Clin Lymphoma Myeloma Leuk. 2020 Sep;20 Suppl 1:S37-S38. doi: 10.1016/S2152-2650(20)30455-9.
Burkitt's lymphoma (BL) is a rare and highly aggressive Non-Hodgkin lymphoma (NHL) with a germinal center phenotype, a nearly universal myc oncogene translocation to an enhancer element and a proliferation index greater than 95%. Bcl-2 is not expressed as opposed to double-hit or triple-hit lymphoma. Genetic mutations and aberrancy involving the phosphatidylcholine 3-kinase and cyclin-dependent kinase pathways are also involved. Rarely patients present with stage I disease and others are considered as high risk if greater than stage I or with elevated LDH or masses greater than 10 cm.
伯基特淋巴瘤（BL）是一种罕见且高度侵袭性的非霍奇金淋巴瘤（NHL），具有生发中心表型，几乎普遍存在 myc 癌基因易位至增强子元件，且增殖指数大于 95%。与双打击或三打击淋巴瘤相反，Bcl-2 不表达。还涉及涉及磷脂酰胆碱 3-激酶和细胞周期蛋白依赖性激酶途径的遗传突变和异常。罕见的患者表现为 I 期疾病，如果大于 I 期或 LDH 升高或肿块大于 10cm，则被认为是高危患者。
