Causse X, Meyer F, Bergeret A, Faure J L, Paliard P
Service d'hépatogastroentérologie, Hôpital E. Herriot, Lyon.
Gastroenterol Clin Biol. 1988 Mar;12(3):262-4.
Hemolytic anemia was observed in a 36 year-old liver transplant patient. The immunosuppressive regimen included cyclosporine A and prednisolone. Hemolysis appeared a few days after amoxicillin treatment. The presence of anti-D allo-antibodies, auto-antibodies active against erythrocytes, and an immuno-allergic phenomenon against erythrocytic membrane coated by cyclosporine was demonstrated. Increase of daily dose of prednisolone without modification of cyclosporine doses was followed by the disappearance of allo- and auto-sensitization. The role of amoxicillin in promoting these hemolytic phenomenons may be suggested.
在一名36岁的肝移植患者中观察到溶血性贫血。免疫抑制方案包括环孢素A和泼尼松龙。溶血在阿莫西林治疗几天后出现。证实存在抗-D同种抗体、对红细胞有活性的自身抗体以及针对环孢素包被的红细胞膜的免疫过敏现象。在不改变环孢素剂量的情况下增加泼尼松龙的日剂量后，同种和自身致敏现象消失。阿莫西林在促进这些溶血现象中所起的作用值得探讨。
