Jafari-Maskouni Saber, Shahraki Mansour, Daneshi-Maskooni Milad, Dashipour Alireza, Shamsi-Goushki Ali, Mortazavi Zinat
Department of Nutrition, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Department of Nutrition, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran.
Nutr Metab (Lond). 2020 Aug 26;17:74. doi: 10.1186/s12986-020-00494-4. eCollection 2020.
Diabetes mellitus is the most common metabolic disorder worldwide. We aimed to determine the metabolic and clinical responses to Bunium Persicum (Black Caraway) supplementation in overweight and obese patients with T2DM.
Participant recruitment took place in the diabetic clinic of Bu-Ali hospital in Zahedan. Due to the eligibility criteria, 60 participants were randomly placed into two groups, namely placebo ( = 30) and BP ( = 30). The supplementation was considered one 1000 mg capsule 2 times /day BP by meals (lunch and dinner) for 8 weeks. Physical activity levels, dietary intakes, anthropometric measurements [weight, height, and waist circumference], glycemic indices [fasting blood glucose (FBG) and insulin (FBI)], blood lipids [triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c)], and serum nesfatin-1 level were determined. Homeostasis model assessment-insulin resistance (HOMA-IR), Quantitative insulin sensitivity checks index (QUICKI), and Body Mass Index (BMI) were computed.
In comparison with placebo, BP significantly decreased FBG, HOMA-IR, and BMI (). The differences in the FBI, QUICKI, TG, TC, LDL, HDL, WC, and Nesfatin-1 were not significant ().
BP supplementation improved serum glucose indices and BMI among overweight and obese T2DM patients. Further trials are needed to confirm results.
Iranian Registry of Clinical Trials (IRCT), IRCT20181207041876N1, Registered 18/01/2019, https://irct.ir/trial/35752.
糖尿病是全球最常见的代谢紊乱疾病。我们旨在确定黑种草籽补充剂对超重和肥胖2型糖尿病患者的代谢及临床反应。
在扎黑丹布阿里医院的糖尿病门诊招募参与者。根据纳入标准，60名参与者被随机分为两组，即安慰剂组（n = 30）和黑种草籽组（n = 30）。补充剂为每餐（午餐和晚餐）服用一粒1000毫克胶囊，每天两次，持续8周。测定身体活动水平、饮食摄入量、人体测量指标[体重、身高和腰围]、血糖指标[空腹血糖（FBG）和胰岛素（FBI）]、血脂[甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-c）和低密度脂蛋白胆固醇（LDL-c）]以及血清奈斯芬汀-1水平。计算稳态模型评估胰岛素抵抗（HOMA-IR）、定量胰岛素敏感性检查指数（QUICKI）和体重指数（BMI）。
与安慰剂组相比，黑种草籽组显著降低了FBG、HOMA-IR和BMI（）。FBI、QUICKI、TG、TC、LDL、HDL、WC和奈斯芬汀-1的差异不显著（）。
补充黑种草籽可改善超重和肥胖2型糖尿病患者的血糖指标和BMI。需要进一步试验来证实结果。
伊朗临床试验注册中心（IRCT），IRCT20181207041876N1，2019年1月18日注册，https://irct.ir/trial/35752 。
