1 Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Education and Research, Hamdard University, New Delhi, India.
2 HIMT College of Pharmacy, Gr. Noida, Uttar Pradesh, India.
Hum Exp Toxicol. 2019 Jul;38(7):823-832. doi: 10.1177/0960327119842248. Epub 2019 Apr 12.
Nonalcoholic fatty liver disease (NAFLD) is caused by fat accumulation and is related with obesity and oxidative stress. In this study, we investigated the effect of cuminaldehyde on NAFLD in rats fed a high fat diet (HFD). Male Wistar rats were fed a HFD for 42 days to induce NAFLD. The progression of NAFLD was evaluated by histology and measuring liver enzymes (alanine transaminase and aspartate transaminase), serum and hepatic lipids (total triglycerides and total cholesterol), and oxidative stress markers (thiobarbituric acid reactive substances, glutathione, superoxide dismutase, and catalase). The HFD feeding increased the liver weight and caused NAFLD, liver steatosis, hyperlipidemia, oxidative stress, and elevated liver enzymes. Administration of cuminaldehyde ameliorated the changes in hepatic morphology and liver weight, decreased levels of liver enzymes, and inhibited lipogenesis. Our findings suggest that cuminaldehyde could improve HFD-induced NAFLD via abolishment of hepatic oxidative damage and hyperlipidemia. Cuminaldehyde might be considered as a potential aromatic compound in the treatment of NAFLD and obesity through the modulation of lipid metabolism.
非酒精性脂肪性肝病（NAFLD）是由脂肪堆积引起的，与肥胖和氧化应激有关。在这项研究中，我们研究了肉桂醛对高脂饮食（HFD）喂养大鼠 NAFLD 的影响。雄性 Wistar 大鼠喂养 HFD 42 天以诱导 NAFLD。通过组织学和测量肝酶（丙氨酸转氨酶和天冬氨酸转氨酶）、血清和肝脂质（总甘油三酯和总胆固醇）以及氧化应激标志物（硫代巴比妥酸反应物质、谷胱甘肽、超氧化物歧化酶和过氧化氢酶）来评估 NAFLD 的进展。HFD 喂养增加了肝脏重量并导致 NAFLD、肝脂肪变性、高脂血症、氧化应激和肝酶升高。肉桂醛的给药改善了肝形态和肝脏重量的变化，降低了肝酶的水平，并抑制了脂肪生成。我们的研究结果表明，肉桂醛可以通过消除肝氧化损伤和高脂血症来改善 HFD 诱导的 NAFLD。肉桂醛可能通过调节脂质代谢被认为是治疗 NAFLD 和肥胖的潜在芳香化合物。
