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墨西哥2型糖尿病患者糖化血红蛋白水平与肌浆网钙ATP酶蛋白表达水平的负相关关系。

Inverse correlation between levels of glycated haemoglobin and expression levels of SERCA protein in Mexican patients with type 2 diabetes mellitus.

作者信息

Galindo-Hernandez Octavio, Machado-Contreras Jesus Rene, Martinez-Corella Rodrigo, Romero-Garcia Tatiana, Vazquez-Jimenez J Gustavo

机构信息

Facultad de Medicina Mexicali, Universidad Autonoma de Baja California, Mexico.

Departamento de Bioquímica, Cinvestav-IPN, Mexico.

出版信息

Arch Med Sci. 2020 Aug 10;16(5):1226-1228. doi: 10.5114/aoms.2020.97970. eCollection 2020.

DOI:10.5114/aoms.2020.97970
PMID:32864012
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7444701/
Abstract

We examined the association between sarco/endoplasmic reticulum calcium ATPase (SERCA) expression and glycated hemoglobin (HbA) levels since alterations in this protein expression are associated with the genesis of insulin resistance. HbA1c levels and SERCA protein expression from platelets of Mexican patients diagnosed with type 2 diabetes mellitus (T2DM) were analyzed showing lower values of SERCA expression against the normal values we find in healthy people. Interestingly, as diabetes condition got worse; SERCA protein expression decreased gradually until it was undetectable. The results showed an inverse correlation between HbA and SERCA protein expression in T2DM patients. .

摘要

由于该蛋白表达的改变与胰岛素抵抗的发生有关，我们研究了肌浆网/内质网钙ATP酶（SERCA）表达与糖化血红蛋白（HbA）水平之间的关联。分析了墨西哥2型糖尿病（T2DM）患者血小板中的糖化血红蛋白A1c（HbA1c）水平和SERCA蛋白表达，结果显示，与我们在健康人群中发现的正常值相比，SERCA表达值较低。有趣的是，随着糖尿病病情加重，SERCA蛋白表达逐渐降低，直至无法检测到。结果表明，T2DM患者的HbA与SERCA蛋白表达呈负相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9573/7444701/ca4c520c8e08/AMS-16-5-41535-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9573/7444701/ca4c520c8e08/AMS-16-5-41535-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9573/7444701/ca4c520c8e08/AMS-16-5-41535-g001.jpg

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本文引用的文献

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Biochemical markers of type 2 diabetes as a late complication of myocardial infarction: a case-control study.2型糖尿病作为心肌梗死晚期并发症的生化标志物：一项病例对照研究。
Arch Med Sci. 2017 Mar 1;13(2):311-320. doi: 10.5114/aoms.2017.65240. Epub 2017 Jan 19.
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Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression.棕榈酸而非棕榈油酸通过降低肌浆网钙ATP酶泵的表达，在人内皮细胞系中诱导胰岛素抵抗。
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Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity.肌浆/内质网钙转运 ATP 酶 2b 是肥胖症中内质网应激和葡萄糖内稳态的主要调节因子。
Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19320-5. doi: 10.1073/pnas.1012044107. Epub 2010 Oct 25.
7
Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone.2型糖尿病患者血小板肌浆网钙ATP酶和μ-钙蛋白酶活性发生改变，罗格列酮可使其恢复。
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8
Comparison of five methods for determination of total plasma protein concentration.五种测定血浆总蛋白浓度方法的比较。
J Biochem Biophys Methods. 2007 Aug 1;70(5):709-11. doi: 10.1016/j.jbbm.2007.05.009. Epub 2007 May 31.
9
The antidiabetic agent rosiglitazone upregulates SERCA2 and enhances TNF-alpha- and LPS-induced NF-kappaB-dependent transcription and TNF-alpha-induced IL-6 secretion in ventricular myocytes.抗糖尿病药物罗格列酮上调肌浆网钙ATP酶2（SERCA2），并增强肿瘤坏死因子-α（TNF-α）和脂多糖（LPS）诱导的心室肌细胞中核因子-κB（NF-κB）依赖性转录以及TNF-α诱导的白细胞介素-6（IL-6）分泌。
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Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.内质网应激将肥胖、胰岛素作用和2型糖尿病联系起来。
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